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MetabolomicsMetabolomics analysis reveals the participation of efflux pumps and ornithine in the response of Pseudomonas putida DOT-T1E cells to challenge with propranolol
Efflux pumps are critically important membrane components that play a crucial role in strain tolerance in Pseudomonas putida to antibiotics and aromatic hydrocarbons that result in these toxicants being expelled from the bacteria. Here, the effect of propranolol on P. putida was examined by sudden a...
2016-08-23 | MTBLS320 | MetaboLights
ProteomicsA genetic platform to investigate the functions of bacterial drug efflux pumps
Efflux pumps are a significant challenge for the development of new antibacterial agents. Overcoming efflux requires an in-depth understanding of efflux pump functions, substrate specificities, and the development of inhibitors. However, the complexities of drug efflux networks have limited such stu...
ORGANISM(S): Escherichia coli 
2022-08-31 | PXD033975 | Pride
Escherichia coli Efflux pumps 
GenomicsFunctional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosa
Functional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosa
PRJNA1197429 | ENA
TranscriptomicsBile-induced biofilm formation in Bacteroides thetaiotaomicron requires magnesium efflux by an RND pump
The study is about the role of Bacteroides thetaiotaomicron in the human gut microbiota, specifically its ability to form biofilms in response to bile salts. The study found that bile induces the expression of certain efflux pumps, and inhibiting these pumps impairs biofilm formation. Among the indu...
ORGANISM(S): Bacteroides thetaiotaomicron 
2024-03-19 | E-MTAB-13460 | biostudies-arrayexpress
GenomicsPhysiology of Pseudomonas aeruginosa cells without major RND-type multidrug efflux pumps
Physiology of Pseudomonas aeruginosa cells without major RND-type multidrug efflux pumps
PRJNA714944 | ENA
TranscriptomicsFunctional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic human pathogen, which is ubiquitous in the environment. The environmental versatility of P. aeruginosa is often attributed to a large arsenal of active efflux pumps, low permeability of the outer membrane and extensive regulatory networks. In this study, we...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-03-01 | GSE284138 | GEO
TranscriptomicsMutations in Multidrug Efflux Pumps of Eshcerichia coli
The number and overlapping substrate repertoire of multidrug efflux pumps in the E. coli genome suggest a physiological role apart from multidrug resistance. This role was investigated using transcriptomic analyses of cDNAs labeled from E. coli AG102 mRNA (hyper drug resistant, marR1) and its isogen...
ORGANISM(S): Escherichia coli 
2008-03-11 | GSE10757 | GEO
GenomicsPyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display antivirulence potential
Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display antivirulence potential
PRJNA865169 | ENA
TranscriptomicsDeciphering the role of RND efflux transporters in Burkholderia cenocepacia D4
To compare the expression profile of B. cenocepacia mutants impaired in RND efflux pump encoding genes
ORGANISM(S): Burkholderia cenocepacia 
2011-04-23 | E-MEXP-2999 | biostudies-arrayexpress
TranscriptomicsDeciphering the role of RND efflux transporters in Burkholderia cenocepacia D9 and D4-D9
To compare the expression profile of B. cenocepacia mutants impaired in RND efflux pump encoding genes
ORGANISM(S): Burkholderia cenocepacia 
2011-04-23 | E-MEXP-2997 | biostudies-arrayexpress
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