Sort   by:  
 Page size 
GenomicsPrinciples of ER Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling
Principles of ER Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling
PRJNA260073 | ENA
OtherPrinciples of ER Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling
Localized protein synthesis is a fundamental mechanism for creating distinct subcellular environments. Here we developed a generalizable proximity-specific ribosome profiling strategy that enables global interrogation of translation in defined subcellular locations. We applied this approach to the e...
ORGANISM(S): Saccharomyces cerevisiae Homo sapiens 
2014-11-10 | GSE61012 | GEO
ProteomicsA proteomic study on the membrane protein fraction of T cells confirms high substrate selectivity for the ER translocation inhibitor cyclotriazadisulfonamide
Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of type I integral membrane protein human CD4 (huCD4) across the ER in a signal peptide (SP)-dependent way. Previously, sortilin was identified as a secondary substrate for CADA but showed reduced CADA sensitivity as compare...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD027712 | Pride
Cd4  cyclotriazadisulfonamide (cada)  er co-translational translocation  signal peptide  silac 
GenomicsSAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
PRJNA917767 | ENA
UnknownSignal peptide-binding drug as a selective inhibitor of co-translational protein translocation.
Not available
S-EPMC4251836 | biostudies-literature
UnknownThe signal sequence influences post-translational ER translocation at distinct stages.
Not available
S-EPMC3793985 | biostudies-literature
OtherSAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
Translocon clogging at the endoplasmic reticulum (ER) as a result of translation stalling triggers ribosome UFMylation, activating Translocation-Associated Quality Control (TAQC) to degrade clogged substrates. How cells sense ribosome UFMylation to initiate TAQC is unclear. We conduct a genome-wide ...
ORGANISM(S): Homo sapiens 
2023-01-20 | GSE222104 | GEO
UnknownBioreactor-scale cell performance and protein production can be substantially increased by using a secretion signal that drives co-translational translocation in Pichia pastoris.
Not available
S-EPMC7680431 | biostudies-literature
UnknownSAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum.
Not available
S-EPMC10010011 | biostudies-literature
ProteomicsUFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
Supporting MS data for paper (doi: 10.1038/s41586-024-07073-0) by DaRosa P.A., Penchev I. et al., titled "UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER". Index of MS supporting files uploaded: Related to Related to Fig. 1b, c (xb01004(UFM1), xb01005(SBP-UFM1): LFQ IP-MS (Un...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-22 | MSV000093721 | MassIVE
Sort   by:  
 Page size