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GenomicsMutant p53 cooperates with ETS2 to promote etoposide resistance
This SuperSeries is composed of the following subset Series: GSE36749: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq] GSE36751: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36752 | biostudies-arrayexpress
GenomicsMutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq]
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms including disabling pro-apoptotic proteins and by regulating gene expression. Analysis of promoter regions identified through CHIP-on-CHIP and CHIP-SEQ platforms reveal that the ETS motif (EBS) is prevalent within predic...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36749 | biostudies-arrayexpress
TranscriptomicsMutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip]
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms including disabling pro-apoptotic proteins and by regulating gene expression. Analysis of promoter regions identified through CHIP-on-CHIP and CHIP-SEQ platforms reveal that the ETS motif (EBS) is prevalent within predic...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36751 | biostudies-arrayexpress
TranscriptomicsExpression profile of etoposide-resistant MCF7 (MCF7VP) cells
The second leading cause of cancer death for women in the U.S. is breast cancer. Moreover, a significant number of patients with breast tumors acquire resistance to drugs during therapy. To develop targeted therapeutic strategies to combat drug resistance it is essential to understand the basic mol...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-28413 | biostudies-arrayexpress
TranscriptomicsRNA-seq of sh2-H2AFJ and sh-NoTarget in WI-38hTERT cells induced into senescence by etoposide
Study the role of H2A.J in gene expression in senescent human fibroblasts by comparing RNA-seq of WI-38hTERT fibroblasts expressing either an sh2-H2AFJ or sh-NoTarget RNAs. Senescence was induced by treating cells with 20 M etoposide for 2 weeks followed by one further week of incubation without eto...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-MTAB-4920 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of Etoposide-treated 293 cells expressing p65 wt or p65 S547A
We reported a direct phosphorylation of the Ser547 of the RelA/p65 subunit of NF-kB by ATM kinase. A comparative transcriptomic analyse with HEK293 cells expressing exclusively HA-p65wt or a non-phosphorylable mutant HA-p65S547A was conducted to identify the genes regulated by this phosphorylation a...
ORGANISM(S): Homo sapiens 
2012-05-30 | E-GEOD-33990 | biostudies-arrayexpress
TranscriptomicsRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Determine the effect of knocking out the H2afj gene on the transcriptome of MEFs induced into senescence with etoposide. MEFs were produced from individual H2A.J-ko or isogenic WT C57BL/6-N embryos. 3 different female WT and H2A.J-ko MEFs were used for the transcriptome analyses. MEFs were cultivate...
ORGANISM(S): Mus musculus 
2020-11-02 | E-MTAB-9704 | biostudies-arrayexpress
TranscriptomicsGene expression changes in U937 cells in response to ectopic expression of EVI1 and/or etoposide treatment
Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...
ORGANISM(S): Homo sapiens 
2015-03-10 | E-GEOD-66660 | biostudies-arrayexpress
TranscriptomicsRNA-seq data U2OS human osteosarcoma cell line etoposide treated with JMY knockdown
Effects of JMY on gene expression in U2OS under etoposide treatment
ORGANISM(S): Homo sapiens 
2023-04-20 | E-MTAB-12059 | biostudies-arrayexpress
TranscriptomicsExpression profile of etoposide-resistant MCF7 (MCF7VP) cells with targeted RUNX2 knockdown
The second leading cause of cancer death for women in the U.S. is breast cancer, moreover, a significant number of patients with breast tumors acquire resistance to drugs during therapy. To develop targeted therapeutic strategies to combat drug resistance it is essential to understand the basic mole...
ORGANISM(S): Homo sapiens 
2011-04-08 | E-GEOD-28414 | biostudies-arrayexpress
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