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TranscriptomicsThe tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma
Rap1GAP is a critical tumor suppressor gene that is down-regulated in multiple aggressive cancers such as head and neck squamous cell carcinoma, melanoma and pancreatic cancer. However, the mechanistic basis of rap1GAP down-regulation in cancers is poorly understood. By employing an integrative appr...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-28501 | biostudies-arrayexpress
TranscriptomicsiCLIP analysis of EZH2-interacting RNAs
RNAs directly interacting with EZH2 were isolated from human colorectal HCT116 cells using an in vivo crosslinking and immunoprecipitation strategy (iCLIP, König J et al, Nat Struct Mol Biol 2010) coupled to an ultrasequencing approach. RIP sequencing for 1 Human sample
ORGANISM(S): Homo sapiens 
2012-04-23 | E-GEOD-36070 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of EZH2 knockdown
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-46904 | biostudies-arrayexpress
TranscriptomicsGene expression change in Skov3 after EZH2 knockdown
To identify genes whose expression was suppressed by EZH2, we performed gene expression microarray analysis in control and EZH2 knockdown human SKOV3 EOC cells. Two individual short hairpin RNAs to the human EZH2 gene (shEZH2) were used to limit potential off-target effects. Two individual short hai...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-31433 | biostudies-arrayexpress
TranscriptomicsEZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and h...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-45982 | biostudies-arrayexpress
TranscriptomicsEZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations
This SuperSeries is composed of the following subset Series: GSE40970: ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines GSE40971: Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor GSE41239: Gene express...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40972 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiles of EZH2 activation
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-47476 | biostudies-arrayexpress
TranscriptomicsExpression data of EZH2-dependent genes in prostate cancer cell lines
EZH2 is frequently over-expressed in aggressive and metastatic solid tumors, including castration resistant prostate cancer (CRPC). We sought to determine EZH2-dependent gene expression programmes in prostate cancer progression, and found an intriguing functional switch of EZH2 from a repressor to a...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-39452 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2
We studied transcriptional changes by Affymetrix human microarrays in 2 DLBCL cell lines as a result of shRNA mediated knockdown of EZH2. In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-41239 | biostudies-arrayexpress
TranscriptomicsmRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells
mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2. Human umbilical vein endothelial cells (HUVEC) were transfected with 25 nmol/L of control small interfering RNA (siRNA) (Silencer Select Negative Control Ambion, Austin, TX) or siRNA directed against Ezh2 (s4918;...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41610 | biostudies-arrayexpress
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