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ProteomicsFAM69C functions as a kinase for eIF2α and promotes stress granule assembly
Stress granules are dynamic cytoplasmic ribonucleoprotein granules that assemble in response to cellular stress. Aberrant formation of stress granules has been linked to neurodegenerative diseases. However, the molecular mechanisms underlying the initiation of stress granules remain elusive. Here we...
ORGANISM(S): Homo sapiens (Human) 
2023-04-21 | PXD037697 | Pride
Eif2α  fam69c  inflammasome  stress response  stress granule. 
GenomicsFAM69C promotes stress granule assembly and suppresses inflammasome activation
FAM69C promotes stress granule assembly and suppresses inflammasome activation
PRJNA886455 | ENA
GenomicsSingle-cell RNA sequencing of cortical samples in Fam69c knockout mice
Single-cell RNA sequencing of cortical samples in Fam69c knockout mice
PRJNA839396 | ENA
TranscriptomicsFAM69C promotes stress granule assembly and suppresses inflammasome activation
Stress granule and inflammasome assembly determine contrasting fates of stressed cells. FAM69C is a brain-enriched kinase associated with neurodegenerative diseases, but its biological functions are still largely unknown. Here we show that FAM69C plays an important role in the regulation of stress r...
ORGANISM(S): Mus musculus 
2022-10-05 | GSE214646 | GEO
TranscriptomicsSingle-cell RNA sequencing of cortical samples in Fam69c knockout mice
Synapse loss and memory decline are the primary features of neurodegenerative dementia. However, molecular underpinnings that drive memory loss remain largely unknown. Here, we report that FAM69C is a novel kinase critically involved in neurodegenerative dementia. Biochemical analyses uncovered that...
ORGANISM(S): Mus musculus 
2022-06-30 | GSE203311 | GEO
UnknownFAM69C functions as a kinase for eIF2α and promotes stress granule assembly.
Not available
S-EPMC10157376 | biostudies-literature
UnknownFAM69C functions as a kinase for eIF2α and promotes stress granule assembly
Not available
S-SCDT-10_15252-EMBR_202255641 | biostudies-other
UnknownA novel predicted calcium-regulated kinase family implicated in neurological disorders.
Not available
S-EPMC3696010 | biostudies-literature
UnknownGenome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
Not available
S-EPMC5622124 | biostudies-literature
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