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ProteomicsEvaluation of a Pooling Chemoproteomics Strategy with an FDA-approved Drug Library
Chemoproteomics is a key platform for characterizing the mode of action (MoA) for compounds, especially for targeted protein degraders such as proteolysis targeting chimerics (PROTACs) and molecular glues. With deep proteome coverage, multiplexed tandem mass tag-mass spectrometry (TMT-MS) can tackle...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033780 | Pride
Mass spectrometry  proteomics  chemoproteomics  tandem mass tag  pooling strategy  protac  molecular glue  targeted protein degeneration  fda library 
MetabolomicsGNPS-FDA(Selleckchemicals)_NIHcollectionIandII
http://www.nihclinicalcollection.com/index.php http://www.selleckchem.com/screening/fda-approved-drug-library.html#chemicallib
ORGANISM(S): Drug Library 
2014-03-19 | MSV000078567 | GNPS
TranscriptomicsPemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma
We devised a high-throughput, cell-based assay to identify novel therapeutic compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs, grown as neurospheres, were screened against a library of approximately 7,000 compounds including FDA-approved drugs. We identified two FDA-approved drugs, ...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-46406 | biostudies-arrayexpress
UnknownScreening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library.
Not available
S-EPMC6069169 | biostudies-literature
UnknownFDA Approved Drug Library Screening Identifies Robenidine as a Repositionable Antifungal.
Not available
S-EPMC7283467 | biostudies-literature
UnknownEvaluation of a Pooling Chemoproteomics Strategy with an FDA-Approved Drug Library.
Not available
S-EPMC9905291 | biostudies-literature
UnknownClinicalTrials.gov and Drugs@FDA: A Comparison of Results Reporting for New Drug Approval Trials.
Not available
S-EPMC5028264 | biostudies-literature
UnknownIn silico screening of potent inhibitors against COVID-19 key targets from a library of FDA-approved drugs.
Not available
S-EPMC8475441 | biostudies-literature
UnknownScreen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6.
Not available
S-EPMC12151230 | biostudies-literature
UnknownZika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an FDA-approved library.
Not available
S-EPMC5112578 | biostudies-literature
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