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MetabolomicsMetabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites
The objective of the study was to identify the fertility-associated metabolites in bovine spermatozoa using liquid chromatography-mass spectrometry (LC-MS). Six Holstein Friesian crossbred bulls (three high-fertile and three low-fertile bulls) were the experimental animals. Sperm proteins were isola...
2021-12-07 | MTBLS1071 | MetaboLights
ProteomicsComprehensive Proteomics Analysis of Bovine Sperm Head Plasma Membrane Associated with Fertility
Bull fertility impacts herd fertility, but accurately predicting male fertility from sperm characteristics is difficult once extremes are removed. The objectives of this study are identification, relative quantification, and comparison of sperm head plasma membrane (HPM) proteomics in bulls of diffe...
ORGANISM(S): Bos taurus (Bovine) 
2026-06-08 | PXD047294 | Pride
Fertility biomarkers Proteomics analysis Bull fertility Sperm head plasma membrane 
TranscriptomicsTestis transcriptome alterations in zebrafish (Danio rerio) with reduced fertility due to developmental exposure to 17alpha-ethynylestradiol
17α-Ethinylestradiol (EE2) is a ubiquitous aquatic contaminant shown to decrease fish fertility at low concentrations, especially in fish exposed during development. The mechanisms of the decreased fertility are not fully understood. In this study, we perform transcriptome analysis by RNA sequencing...
ORGANISM(S): Danio rerio 
2017-12-09 | E-MTAB-6251 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3 wild-type and 3 Crtc1 knockouts reveals the Creb1 coactivator Crtc1 is required for energy balance and fertility
The adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (Leprs) that trigger the signal transducer and activator of transcription 3 (Stat3). Although disruption of Lepr-Stat3 signaling promotes obesity in mice, other features of Lepr function, such as...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-12209 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Foxo3 mutant ovaries vs. wild types to discover and classify ovarian fertility factors.
Female infertility syndromes are among the most prevalent chronic health disorders in women, but their molecular basis remains unknown because of the complexity of oogenesis and uncertainty regarding the number and identity of ovarian factors controlling the assembly, preservation, and maturation of...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8249 | biostudies-arrayexpress
TranscriptomicsEffect of miR-106b~25 in mouse spermatogenesis and male fertility
We investigated the miRNA cluster miR-106b~25 as potential candidate causing male infertility. We analized single and double KO mice. Single KO show derregulation of multiple molecular pathways and disrupted early spermatogenesys, but retain fertility. Double KO show severely disrupted testicular hi...
ORGANISM(S): Mus musculus 
2020-11-06 | E-MTAB-8964 | biostudies-arrayexpress
UnknownFertility patients' use and perceptions of online fertility educational material.
Not available
S-EPMC7368747 | biostudies-literature
GenomicsDirect but No Transgenerational Effects of Decitabine and Vorinostat on Male Fertility
Epigenetic drugs actively altering the epigenome of tumours have been developed for use in anti-cancer therapies. However, these drugs could potentially also affect the DNA methylome of spermatozoa that seems to be essential for male fertility. Here, we analysed possible direct and transgenerational...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-59575 | biostudies-arrayexpress
TranscriptomicsEffects of fertility on gene expression and function of the bovine endometrium
To identify heifers of contrasting fertility, serial rounds of artificial insemination (AI) were conducted in 201 synchronized crossbred beef heifers. The heifers were then fertility classified based on number of pregnancies detected on day 35 in the four AI opportunities. The reproductive tracts ...
ORGANISM(S): Bos taurus 
2013-04-23 | E-GEOD-46274 | biostudies-arrayexpress
TranscriptomicsThe tomato MYB21 acts in ovules to mediate jasmonate-regulated fertility (RNASeq)
The function of the plant hormone jasmonic acid (JA) in development of tomato flowers was analyzed with a mutant defective in JA perception (jasmonate-insensitive1-1, jai1-1). In contrast to Arabidopsis JA-insensitive plants that are male sterile, the tomato mutant jai1-1 exhibits major defects in f...
ORGANISM(S): Solanum lycopersicum 
2019-11-05 | E-MTAB-7545 | biostudies-arrayexpress
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