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ProteomicsQuantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-stimulated Macrophages
There is a present need to develop alternative biotherapeutic drugs to mitigate the exacerbated inflammatory immune responses characteristic of sepsis. The potent endotoxin lipopolysaccharide (LPS), a major component of Gram-negative bacterial outer membrane, activates the immune system via Toll-lik...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD065520 | Pride
Tmt-labeling  proteomics  fasciola hepatica  fh15  tlr  nf-κb  inos  cd36  lck  lps  macrophages  sepsis 
Genomics
Effects of the anti-inflammatory Fh15 protein on the gut microbiota of an Ulcerative colitis mice model induced by DSS
PRJEB103757 | ENA
UnknownRecombinant Fasciola hepatica fatty acid binding protein suppresses toll-like receptor stimulation in response to multiple bacterial ligands.
Not available
S-EPMC5511235 | biostudies-literature
UnknownRecombinant Fasciola hepatica Fatty Acid Binding Protein as a Novel Anti-Inflammatory Biotherapeutic Drug in an Acute Gram-Negative Nonhuman Primate Sepsis Model.
Not available
S-EPMC8694124 | biostudies-literature
UnknownQuantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages
Not available
S-EPMC12294962 | biostudies-literature
UnknownStructural basis for engagement by complement factor H of C3b on a self surface.
Not available
S-EPMC3512577 | biostudies-literature
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