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TranscriptomicsProteogenomics uncovers critical elements of host response in bovine soft palate epithelial cells following in vitro infection with foot-and-mouth disease virus (FMDV)
The pathogen and host factors that contribute to the establishment of foot-and-mouth disease virus (FMDV) persistence are currently not understood. Using primary bovine soft palate multilayers in combination with RNA sequencing, we analyzed the transcriptional responses during acute and persistent F...
ORGANISM(S): Bos taurus 
2019-01-18 | E-MTAB-7605 | biostudies-arrayexpress
ProteomicsProteogenomics uncovers critical elements of host response in bovine soft palate epithelial cells following in vitro infection with foot-and-mouth disease virus (FMDV)
: Foot-and-mouth disease (FMD) is the most devastating disease of cloven-hoofed livestock, with a crippling economic burden in endemic areas and immense costs associated with outbreaks in free countries. Foot-and-mouth disease virus (FMDV), a picornavirus, will spread rapidly in naïve populations, r...
ORGANISM(S): Bos taurus (Bovine) 
2019-01-17 | PXD012242 | Pride
Foot-and-mouth disease virus (fmdv)  bovine soft palate  nasopharynx  transcriptomics  proteomics  bioinformatics  virus-host interaction  innate immune system  interferon-stimulated genes (isg) 
TranscriptomicsRNA-Seq of persistent foot-and-mouth disease virus infection in the bovine nasopharynx
In our study, we examined tissue samples from 20 cattle that had been experimentally infected with the FMDV strain O/FRA/1/2001. In 18 of these animals, the infection persisted for more than 28 days. At necropsy, epithelial tissue was collected from the dorsal nasopharynx and dorsal soft palate, the...
ORGANISM(S): Bos taurus 
2025-07-01 | E-MTAB-14394 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression for FMDV-infected RAW264.7 cell
To determine whether type O FMDV-infected macrophage can release a variety of cytokines and activate innate immune responses, we have taken systematic functional genomics studies using microarray technology on differences expression gene of FMDV-infected and FMDV-uninfected mouse monocyte macrophage...
ORGANISM(S): Mus musculus Mus 
2017-03-15 | GSE96588 | GEO
TranscriptomicsTranscriptomic analysis genes involved in the establishment and maintenance of FMDV persistent infection
In FMDV persistent infection cell lines, we found that many FMDV-free cells (BHK_VEC) occupied. The BHK_VEC cells exhibited resisted to the parental FMDV, and could re-establish a persistent infection when infected with FMDV-OP, revealing a fact that host cells evolved during the persistent infectio...
ORGANISM(S): Mesocricetus auratus 
2018-03-22 | GSE93045 | GEO
GenomicsTranscriptome analysis of total blood cells from sheep after vaccination with FMDV vaccines
Transcriptome analysis of total blood cells from sheep after vaccination with FMDV vaccines
PRJNA559411 | ENA
TranscriptomicsTranscriptome analysis of total blood cells from sheep after vaccination with FMDV vaccines
Transcriptome analysis of total blood cells from sheep collected at 0, 4 and 24 hours after vaccination with inactivated FMDV vaccine, and adenovirus (human Ad5)-based vaccines encoding FMDV antigens, with and without Montanide ISA206 VG adjuvant.
ORGANISM(S): Ovis aries 
2019-12-10 | GSE135609 | GEO
TranscriptomicsMechanisms of Tissue Susceptibility to FMDV Persistent Infection Based on Genes Differentially Expressed between Target and Non-target Tissues
Comparison of the transcriptiomic profiles using DNA microarray analysis betwween the pharyneal (target of FMDV acute and persistent infection) and lung (target of FMDV acute infection) tissues of cattle
ORGANISM(S): Bos taurus 
2023-09-01 | GSE232440 | GEO
UnknownFMDV 3A cooperates with PDCD10 to promote FMDV replication by inhibiting VISA-mediated innate immunity.
Not available
S-EPMC12724370 | biostudies-literature
UnknownKIF5B-mediated internalization of FMDV promotes virus infection.
Not available
S-EPMC11279799 | biostudies-literature
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