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ProteomicsHuman Treg LC-MSMS - Foxp3 drives oxidative phosphorylation and protection from lipotoxicity
Regulatory T cells (Treg) have been shown to adopt a catabolic metabolic programme with increased capacity for fatty acid oxidation fuelled oxidative phosphorylation (OXPHOS). The role of Foxp3 in this metabolic shift is poorly understood. Here we show that Foxp3 was sufficient to induce a significa...
ORGANISM(S): Homo sapiens (Human) 
2017-02-15 | PXD001906 | Pride
Human t cell treg foxp3 lc-msms 
TranscriptomicsFoxp3 expression is required for the induction of therapeutic tissue tolerance
CD4+Foxp3+ regulatory T cells (Treg) are essential for immune homeostasis and maintenance of self-tolerance. They are produced in the thymus and also generated de novo in the periphery in a TGFB dependent manner. Foxp3+ Treg are also required to achieve tolerance to transplanted tissues when induced...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39529 | biostudies-arrayexpress
GenomicsFoxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq]
Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new ...
ORGANISM(S): Mus musculus 
2012-09-28 | E-GEOD-40684 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD4+ T cells gene-transduced with AML1, wild type Foxp3, and a Foxp3 mutant defective in binding to AML1
To clarify how Foxp3 regulates its target genes, we performed co-immunoprecipitation experiments and found that Foxp3 physically bound to AML1/Runx1 (Ono, M. et al, Nature, 2007). In this series of study, we compared gene regulations by AML1, wild type Foxp3, and a Foxp3 mutant with defective bindin...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6939 | biostudies-arrayexpress
ProteomicsFoxp3 positive and negative cell comparison
Regulatory T cells have been shown to adopt a catabolic metabolic programme with increased capacity for fatty acid oxidation fuelled oxidative phosphorylation (OXPHOS). The role of Foxp3 in this metabolic shift is poorly understood. Here we show that Foxp3 was sufficient to induce a significant incr...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-15 | PXD001789 | Pride
Mouse t cells 
GenomicsFoxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification
This SuperSeries is composed of the following subset Series: GSE40684: Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq] GSE40685: Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [Expression] Refer to in...
ORGANISM(S): Mus musculus 
2012-09-28 | E-GEOD-40686 | biostudies-arrayexpress
TranscriptomicsConserved non-coding sequence 2 (CNS2) of the Foxp3 genomic locus is essential for the function and stability of regulatory T cells during their activation
Regulatory T (Treg) cells play an indispensable role in immune homeostasis. The development and function of Tregs are dependent on transcriptional factor Foxp3, but how constant expression of Foxp3 is maintained in Tregs is not clear. Here we show that ablation of the conserved non-coding DNA seque...
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-57272 | biostudies-arrayexpress
ProteomicsIdentify proteins at Foxp3 bound cis-regulatory elements in situ
We hypothesize that nuclear factors co-occupying the genetic elements with regulatory T (Treg) cell lineage–specifying factor Foxp3 play critical roles in transcriptional regulation of Treg immune suppression function, thus, offering a unique approach to investigate the factors and their mechanisms ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-08 | PXD019050 | Pride
Proximity ligation Proteomics Foxp3 
TranscriptomicsTranscription profiling of mouse thymic T cells - Foxp3-dependent programme of regulatory T-cell differentiation (GEO Super Series0
This SuperSeries is composed of the following subset Series:; GSE7280: Gene expression in peripheral cells: effects of Foxp3 and PDE3B; GSE7770: Gene expression in thymic CD4 T cells: effects of Foxp3 Experiment Overall Design: Thymocyte RNA (GSE7770) was processed with Affy and Enzo reagents wherea...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7773 | biostudies-arrayexpress
TranscriptomicsExpression data between FOXP3 wild type and 2T>C(mut)
Investigation of the role of FOXP3 in CD4+ T effector cells. FOXP3 is transiently upregulated in T effector cells under activation. This temporary expression in Teff cells is insufficient to suppress expression of reported targets of FOXP3 repressor activity. The role of FOXP3 in T effector cells re...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-41087 | biostudies-arrayexpress
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