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MetabolomicsThe role of FYCO1-dependent autophagy in lens fiber cell differentiation.

FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts wit...

2024-03-24 | MTBLS206 | MetaboLights
ProteomicsThe indispensable role of autophagy in lens morphogenesis
FYVE and coiled-coil domain containing 1 (FYCO1) is expressed ubiquitously and is required for microtubule-dependent, plus-end-directed transport of autophagic vesicles. We previously reported the loss of function mutations in FYCO1 responsible for cataractogenesis with no other ocular and/or extra-...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD017001 | Pride
Mass-spectrometry H9 hesc-derived lentoid bodies Tmt Proteome 
ProteomicsThe autophagic protein FYCO1 controls TRAIL receptor induced apoptosis and is inactivated by caspase 8
Apoptosis and autophagy are programs of controlled cellular suicide or survival, closely interconnected at multiple levels to ensure balanced answers to stress signals, and often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes microtubule plus end–directed transport of aut...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD033760 | Pride
Apoptosis  autophagy  inflammation  death receptors  endosome maturation  lysosomal degradation  caspase 8  fyco1  ccz1 
UnknownLoss of FYCO1 leads to cataract formation.
Not available
S-EPMC8253827 | biostudies-literature
UnknownThe role of FYCO1-dependent autophagy in lens fiber cell differentiation.
Not available
S-EPMC9397473 | biostudies-literature
UnknownMutations in FYCO1 cause autosomal-recessive congenital cataracts.
Not available
S-EPMC3113247 | biostudies-literature
UnknownFYCO1 Frameshift Deletion in Wirehaired Pointing Griffon Dogs with Juvenile Cataract.
Not available
S-EPMC8871958 | biostudies-literature
UnknownCrystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.
Not available
S-EPMC7397462 | biostudies-literature
UnknownFYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo.
Not available
S-EPMC8093479 | biostudies-literature
UnknownFYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation.
Not available
S-EPMC5769594 | biostudies-literature
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