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GenomicsHistone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma
Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma
PRJNA1423601 | ENA
TranscriptomicsHistone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma
Immune checkpoint inhibitors (ICIs) have improved cancer therapy, but their efficacy in hepatocellular carcinoma (HCC) remains limited, partly associated with tumor-intrinsic mechanisms of immune evasion. To investigate potential epigenetic drivers of immune resistance, this study evaluated transcri...
ORGANISM(S): Homo sapiens Mus musculus 
2026-02-16 | GSE319486 | GEO
TranscriptomicsG9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition
AIM: We performed RNA-sequencing experiments seeking genes whose expression changed due to nerve injury. In addition, we wanted to test whether inhibition of the methyl transferase G9a/GLP, that methylates H3K9me2, could reverse those expression changes due to nerve ligation. G9a/GLP methylase was p...
ORGANISM(S): Rattus norvegicus 
2015-11-02 | E-GEOD-59043 | biostudies-arrayexpress
UnknownG9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.
Not available
S-EPMC5011428 | biostudies-literature
GenomicsH3K9 dimethylation safeguards cancer cells against activation of the Interferon pathway [SUV39H1_ChIP-seq]
Activation of the interferon genes constitutes an important anticancer pathway, able to restrict proliferation of cancer cells. Here we demonstrate that the H3K9me3 histone methyl transferase (HMT) Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) is required for the proliferation of Acute Myeloid L...
ORGANISM(S): Homo sapiens 
2022-03-18 | GSE190469 | GEO
Methylation profilingH3K9 dimethylation safeguards cancer cells against activation of the Interferon pathway [WGBS]
Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here we demonstrate that the H3K9me3 histone methyl transferase (HMT) Suppressor of Variegation 3-9 Homolog 1 (SUV39H1) is required for the proliferation of Acute Myeloid Leukem...
ORGANISM(S): Homo sapiens 
2022-03-18 | GSE182056 | GEO
TranscriptomicsH3K9 dimethylation safeguards cancer cells against activation of the Interferon pathway [RNA-seq]
Activation of the interferon genes constitutes an important anticancer pathway, able to restrict proliferation of cancer cells. Here we demonstrate that the H3K9me3 histone methyl transferase (HMT) Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) is required for the proliferation of Acute Myeloid L...
ORGANISM(S): Homo sapiens 
2022-03-18 | GSE160531 | GEO
GenomicsH3K9 dimethylation safeguards cancer cells against activation of the Interferon pathway [ChIP-seq]
Activation of the interferon genes constitutes an important anticancer pathway, able to restrict proliferation of cancer cells. Here we demonstrate that the H3K9me3 histone methyl transferase (HMT) Suppressor Of Variegation 3-9 Homolog 1 (SUV39H1) is required for the proliferation of Acute Myeloid L...
ORGANISM(S): Homo sapiens 
2022-03-18 | GSE160530 | GEO
GenomicsProfiling Genome-wide Chromatin Methylation with Engineered Posttranslation Apparatus within Living Cells
We have engineered the chromatin-modifying apparatus and formulated a novel technology, termed Clickable Chromatin Enrichment with parallel DNA sequencing (CliEn-seq), to probe genome-wide chromatin modification within living cells. Examine (E)-hex-2-en-5-ynylation mediated by engineered G9a Y1154A ...
ORGANISM(S): Homo sapiens 
2013-03-04 | E-GEOD-42792 | biostudies-arrayexpress
UnknownTargeted regulation of fibroblast state by CRISPR-mediated CEBPA expression.
Not available
S-EPMC6907247 | biostudies-literature
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