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ProteomicsDIA of Gasdermin-D knockout and cuprizone treated mouse brain tissue
Data-independent acquisition (DIA) of four replicates of mouse brain tissue lysate for each of the four conditions Gasdermin-D WT, Gasdermin-D KO, Gasdermin-D WT treated with cuprizone, and Gasdermin-D KO treated with cuprizone.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-02 | MSV000091185 | MassIVE
ProteomicsE-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/A9 release from neutrophils via transient gasdermin D pore formation
S100A8/A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is still elusive. We report here that E-selectin-induced rapid S100A8/A9 release during ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-25 | PXD041652 | Pride
Neutrophile Inflammation Gasdermin d Transient pore formation 
ProteomicsGasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis infected macrophages
Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis (Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but how these are interconnected and linked to the release of pro-inflammatory cytokines remains unknown. Exploit...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029017 | Pride
Mycobacterium tuberculosis  gasdermin d  interleukin-1β  cell death  esx-1  mitochondria  nlrp3  inflammasome 
ProteomicsGasdermin D-dependent secretome analysis from primary murine microglia
To identify NLRP3-gasdermin D-dependent secreted proteins, wild type or gasdermin D-deficient microglia were treated with NLRP3 agonist (LPS + ATP). Cell-free supernantants from microglia were then analyzed by mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2025-01-07 | PXD051438 | Pride
Mouse Microglia Secretome Lc-ms/ms 
GenomicsGasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction
Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction
PRJNA753787 | ENA
GenomicsControl of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
PRJNA742124 | ENA
ProteomicsMicrobiome-derived hydroxyphenyl propanoate promotes antitumour immunity by enhancing Gasdermin D cleavage in tumour-associated myeloid cells
The microbiome has a significant impact on immune health and response to immune-stimulating treatments, including cancer immunotherapy. However, the molecular mechanisms by which commensal microbes influence cancer immunology remain poorly understood. Here, we report on the discovery of a class of m...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045790 | Pride
Tmt Gasdermin d Hydroxuphenyl pyruvate Thermal profiling Thp1-dual cells 
UnknownGasdermin D: A potential mediator and prognostic marker of bladder cancer.
Not available
S-EPMC9474890 | biostudies-literature
UnknownVastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3.
Not available
S-EPMC11802827 | biostudies-literature
UnknownGasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.
Not available
S-EPMC6347470 | biostudies-literature
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