gastroesophageal reflux disease (gerd)

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Beyond acid suppression: Novel therapeutic targets for gastro-esophageal reflux disease based on a murine model (esophageal tissue)

Background & Aims: Because the pathophysiology of GERD is not fully understood, presently used drug target only one or more of the known underlying mechanisms but are not fully effective in all patients. 1Identifying novel central targets may pave the way to develop more effective agents. Methods: A...

ORGANISM(S): Rattus norvegicus

2015-12-16 | E-GEOD-63401 | biostudies-arrayexpress

Beyond acid suppression: Novel therapeutic targets for gastro-esophageal reflux disease based on a murine model (whole blood)

ORGANISM(S): Rattus norvegicus

2015-12-16 | E-GEOD-63402 | biostudies-arrayexpress

Esophageal epithelium of 12 weeks old mice (WT, Nrf2-/-) on C57BL background with or without gastroesophageal reflux for 4 weeks.

Transcriptional profiling of adult esophageal epithelium comparing wild-type mice with Nrf2-/- mice with or without gastroesophageal reflux for 4 weeks. Goal was to determine the role of Nrf2 on the barrier function of mouse esophageal epithelium. Two-class comparisons. Wild-type/without reflux vs. ...

ORGANISM(S): Mus musculus

2013-01-01 | E-GEOD-39629 | biostudies-arrayexpress

Dynamics of Germinosome Formation Interactions between GerD and Germinant Receptor Subunits in Bacillus cereus Spores

Spores of the bacterium Bacillus cereus can cause disease in humans due to contamination of raw materials for food manufacturing. These dormant, resistant spores can survive for years in the environment, but can germinate and grow when their surroundings become suitable, and spore germination protei...

ORGANISM(S): Bacillus Cereus (ncbitaxon:1396)

2022-01-24 | MSV000088726 | MassIVE

Salivary Hemoglobin Protects against Erosive Tooth Wear in Gastric Reflux Patients

Saliva is the most important biological factor to protect against erosive tooth wear (ETW). Gastroesophageal reflux disease (GERD) patients have an increased risk of ETW due to the frequent presence of intrinsic acids in the oral cavity. Remarkably, not all GERD patients suffer from ETW, which might...

ORGANISM(S): Homo sapiens (Human)

2022-01-19 | PXD030712 | Pride

Multi-omics analysis identifies gut microbiota-glutamine axis contributing to the pathogenesis of reflux esophagitis

Background: Reflux esophagitis (RE), a common gastroesophageal reflux disease characterized by esophageal mucosal inflammation, is closely associated with gut microbiota dysbiosis and metabolic abnormalities. The glutamine-glutamate metabolic pathway regulates inflammation and mucosal barrier fun...

2026-05-03 | MTBLS14421 | MetaboLights

Beyond acid suppression: Novel therapeutic targets for gastro-esophageal reflux disease based on a murine model

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Rattus norvegicus

2015-12-16 | E-GEOD-63403 | biostudies-arrayexpress

Characterisation of the sensory phenotype of the oesophageal mucosa in gastroesophageal reflux disease

PRJNA939567 | ENA

Characterisation of the sensory phenotype of the oesophageal mucosa in gastroesophageal reflux disease

Identification of Novel Immune Cell Signature in Gastroesophageal Reflux Disease: Altered Mucosal Mast Cells and Dendritic Cell Profile. The mechanisms underlying the most troublesome symptom of gastroesophageal reflux disease (GERD), heartburn, remain incompletely understood. The pathogenesis of he...

ORGANISM(S): Homo sapiens

2023-11-20 | GSE226303 | GEO

Co-occurrence of childhood functional constipation and gastroesophageal reflux disease (GERD).

Not available

S-EPMC8818539 | biostudies-literature

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