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ProteomicsKSN01_Proteome_CellLine: Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
ORGANISM(S): Homo Sapiens (human) 
2020-12-15 | PXD010107 | JPOST Repository
TranscriptomicsHuman ES cells reveal recurrent genomic instability at 20q11.21
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we detected a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing about 23 genes in common, appeared in four cell lines of different origins. This amplification, ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-13565 | biostudies-arrayexpress
TranscriptomicsUpregulation of FOXM1 Induces Genomic Instability in Human Epidermal Keratinocytes
Genome-wide 10k SNP profiling of FOXM1B-transduced N/TERT and primary normal human epidermal keratinocytes (NHEK). The aim of this study was to study the cancer initiation role of UVB and FOXM1B upregulation in NHEK. Upregulation of FOXM1B alone (without UVB) was found to directly induce genomic ins...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-16937 | biostudies-arrayexpress
TranscriptomicsThe gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome
Recently, expression profiling of breast carcinomas has revealed gene signatures that predict clinical outcome, and discerned prognostically relevant breast cancer subtypes. Measurement of the degree of genomic instability provides a very similar stratification of prognostic groups. We therefore...
ORGANISM(S): Homo sapiens 
2009-11-30 | E-GEOD-11901 | biostudies-arrayexpress
GenomicsLoss of histone demethylase JARID1C triggers genomic instability in cancer.
Chromatin remodelers are recurrently mutated in cancer. Among these, JARID1C, (KDM5C) a histone demethylase, is frequently inactivated in clear cell renal cell carcinoma (ccRCC) patients. How the genetic inactivation of JARID1C leads to cancer remains largely unknown. Here we report that JARID1C bin...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73267 | biostudies-arrayexpress
TranscriptomicsProgressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the KrasLA2 model of lung cancer. C...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-29230 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for Genomic Instability and Myelodysplasia with Monosomy 7
Gene modified autologous hematopoietic stem cells (HSC) can provide significant clinical benefits to patients suffering from X-linked chronic granulomatous disease (X-CGD), a rare inherited immunodeficiency characterized by recurrent, often life threatening bacterial and fungal infections. Here we...
ORGANISM(S): Homo sapiens 
2010-01-12 | E-GEOD-19523 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of mouse cell lines MMTV-cdc25a;MMTV-neu murine cell line
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4767 | biostudies-arrayexpress
TranscriptomicsAnalysis of genomic instability in esophageal squamous cell carcinoma (ESCC)
To characterize genomic instability in esophageal squamous cell carcinoma, we examined loss of heterozygosity, copy number loss, and copy number gain in ESCC patients from a high-risk region of China. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted fr...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-15526 | biostudies-arrayexpress
TranscriptomicsHigh-resolution genetic analysis of cancer cell lines with near normal karyotypes
Cancer development is associated with multiple genetic alterations and genomic instability either at the chromosomal or base pair level is generally thought to underlie these changes. However, it is still unknown whether genetic instability is absolutely required for tumorigenesis. Here we investig...
ORGANISM(S): Homo sapiens 
2008-03-14 | E-GEOD-8649 | biostudies-arrayexpress
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