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UnknownEnzyme kinetics and inhibition parameters of human leukocyte glucosylceramidase.
Not available
S-EPMC7609449 | biostudies-literature
UnknownMolecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S.
Not available
S-EPMC3009936 | biostudies-literature
UnknownThe Arabidopsis AtGCD3 protein is a glucosylceramidase that preferentially hydrolyzes long-acyl-chain glucosylceramides.
Not available
S-EPMC6970933 | biostudies-literature
UnknownA Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.
Not available
S-EPMC5677758 | biostudies-literature
ProteomicsIdentification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease
Gaucher disease, a recessive inherited metabolic disorder caused by defects in the gene encoding glucosylceramidase (GlcCerase), can be divided into three subtypes according to the appearance of symptoms associated with central nervous system involvement. We now identify a protein, glycoprotein non-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080786 | MassIVE
GenomicsInhibition of the non-lysosomal glucosylceramidase GBA2 accounts for the efficacy of sinbaglustat in a murine model of Sandhoff disease
Inhibition of the non-lysosomal glucosylceramidase GBA2 accounts for the efficacy of sinbaglustat in a murine model of Sandhoff disease
PRJNA1225244 | ENA
UnknownSpecies-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.
Not available
S-EPMC6422076 | biostudies-literature
UnknownPreclinical investigation of artesunate as a therapeutic agent for hepatocellular carcinoma via impairment of glucosylceramidase-mediated autophagic degradation.
Not available
S-EPMC9535011 | biostudies-literature
UnknownSalmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells.
Not available
S-EPMC10179164 | biostudies-literature
TranscriptomicsInhibition of the non-lysosomal glucosylceramidase GBA2 accounts for the efficacy of sinbaglustat in a murine model of Sandhoff disease
Sinbaglustat is a small molecule under investigation as a treatment for lysosomal storage disorders. It inhibits two enzymes involved in glycosphingolipid (GSL) metabolism, the non-lysosomal glucosylceramidase (GBA2) and, with a lower affinity, glucosylceramide synthase (GCS). High doses of structur...
ORGANISM(S): Mus musculus 
2026-02-18 | GSE289884 | GEO
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