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ProteomicsTcdB of Clostridioides difficile mediates necrosis in epithelial cells and is depend on RAS
A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors are TcdA and TcdB, which inhibit small Rho-GTPases. Inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorganization of the actin cytoskeleton, an impair...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD031726 | Pride
Clostridioides difficile  c.diff.  tcdb  phosphoproteomics  ras  tcda  pyknosis  glucosyltransferase independent effect 
UnknownCloning and Characterization of Limonoid Glucosyltransferase from Kinnow Mandarin (Citrus reticulata Blanco).
Not available
S-EPMC6117989 | biostudies-literature
UnknownA collagen glucosyltransferase drives lung adenocarcinoma progression in mice.
Not available
S-EPMC8055892 | biostudies-literature
ProteomicsComparison of DIA and TMT based protein quantification in complex background
Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are among the most popular protein quantification workflows in discovery proteomics. Here, we compared the TMT 10-plex workflow to label free single shot data-independent acquisition (DIA) method on a controlled sample set. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-01-29 | MSV000084859 | MassIVE
TranscriptomicsExpression data from 10-days old dark grown Arabidopsis seedlings of wild type (Col-0), sps1 line and L17 line.
In the present work, experiments were carried out to understand the molecular mechanism underlying phyA’ silencing.The EMS-mutagenesis of phyA’ line, L17, generated suppressor mutations that activate phyA’ locus. Detailed study of one suppressor line, sps1, indicated that methylation of specific CG ...
ORGANISM(S): Arabidopsis thaliana 
2012-06-30 | E-GEOD-36581 | biostudies-arrayexpress
TranscriptomicsEffect of enzyme IIANtr on gene expression in Escherichia coli
Enzyme IIANtr (encoded by ptsN gene) is a component of the nitrogen phosphotransferase system (PTS). It has previously been shown that the dephosphorylated form of EIIANtr is required for the derepression of ilvBN encoding acetohydroxy acid synthase I (AHAS I) catalyzing the first step common to bio...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2010-09-28 | E-GEOD-24373 | biostudies-arrayexpress
UnknownTcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells.
Not available
S-EPMC9024770 | biostudies-literature
TranscriptomicsTranscription profiling of mouse double-positive (CD4+CD8+) thymocytes following dexamethasone treatmen
Glucocorticoids play a role in regulation of T lymphocytes homeostasis and development. In particular, glucocorticoid treatment induces massive apoptosis of CD4+CD8+ double positive (DP) thymocytes. This effect is due to many mechanisms, mainly driven by modulation of gene transcription. To find out...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5463 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis to identify genes responsive to non-metabolised glucose analogs: approach to hexokinase-independent glucose sensing
It has been strongly argued that plant cells should have a means of sensing sugars at the cell surface, so that extracellular and intracellular sugars can be sensed separately and their metabolism coordinated (Lalonde et al., Plant Cell, 11, 707-26, 2000). There is good evidence for an intracellular...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis Col-0 seedlings grown in vitro for 7 days in the absence of sugars, then treated with 30 mM glucose or glucose analogue for 8 h
It has been strongly argued that plant cells should have a means of sensing sugars at the cell surface, so that extracellular and intracellular sugars can be sensed separately and their metabolism coordinated (Lalonde et al., Plant Cell, 11, 707-26, 2000). There is good evidence for an intracellular...
ORGANISM(S): Arabidopsis thaliana 
2003-10-17 | E-NASC-8 | biostudies-arrayexpress
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