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GenomicsGPR124 Protects against Podocyte Senescence and Injury in Diabetic Kidney Disease
GPR124 Protects against Podocyte Senescence and Injury in Diabetic Kidney Disease
PRJNA1180511 | ENA
TranscriptomicsGPR124 Protects against Podocyte Senescence and Injury in Diabetic Kidney Disease
Cellular senescence is associated with the progression of diabetic kidney disease (DKD), and accelerated podocyte senescence promotes the pathogenesis of renal damage. We found that GPR124 was reduced in cultured human podocytes treated with high glucose (HG).To further clarify the role of GPR124 in...
ORGANISM(S): Homo sapiens 
2024-11-05 | GSE280773 | GEO
GenomicsGPR124 regulates murine CNS angiogenesis and blood-brain barrier formation by an intracellular domain-independent mechanism
GPR124 regulates murine CNS angiogenesis and blood-brain barrier formation by an intracellular domain-independent mechanism
PRJNA935353 | ENA
UnknownGPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation.
Not available
S-EPMC6557680 | biostudies-literature
UnknownRECK/GPR124-driven WNT signaling in pancreatic and gastric cancer cells.
Not available
S-EPMC11462976 | biostudies-literature
TranscriptomicsGPR124 regulates murine CNS angiogenesis and blood-brain barrier formation by an intracellular domain-independent mechanism
The GPR124/RECK/WNT7 pathway essentially regulates central nervous system angiogenesis and blood-brain barrier (BBB) function. GPR124, a brain endothelial adhesion 7-pass transmembrane protein, associates with membrane RECK, which binds and stabilizes newly synthesized WNT7 for subsequent transfer t...
ORGANISM(S): Mus musculus 
2024-04-19 | GSE225367 | GEO
UnknownAn integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.
Not available
S-EPMC9171404 | biostudies-literature
UnknownThermosensitive hydrogel-based GPR124 delivery strategy for rebuilding blood-spinal cord barrier.
Not available
S-EPMC10486335 | biostudies-literature
UnknownGPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.
Not available
S-EPMC4331012 | biostudies-literature
UnknownEssential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.
Not available
S-EPMC3099479 | biostudies-literature
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