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MetabolomicsUntargeted metabolomic profiling of HCT116 cells following DHODH and JNK inhibition

Untargeted LC-MS metabolomics was used to investigate metabolic alterations associated with DHODH inhibition and JNK signaling in colorectal cancer. The study included control, DHODH inhibitor treated, JNK inhibitor treated, and combined treatment groups, with pooled quality control samples for a...

2026-08-13 | MTBLS15162 | MetaboLights
MetabolomicsFASN effect on HCT116 metabolism probed by 13C6-glucose tracer (part II)
Not available
ORGANISM(S): Homo sapiens 
ST001046 | MetabolomicsWorkbench
MetabolomicsFASN effect on HCT116 metabolism probed by 13C6-glucose tracer (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001045 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of QUB HCT116 sensitive and resistant colorectal cancer time series
HCT116 parental, HCT116 5-FU resistant and HCT116 oxaliplatin resistant cells have been transiently treated with with their respective drug (5-FU or oxaliplatin) for 0, 6 12 or 24h in 3 independent experiments.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-390 | biostudies-arrayexpress
TranscriptomicsKnockout PTTG1 HCT116 cells
To identify potential PTTG1-targeted genes, total RNA from PTTG1+/+ and PTTG1-/- HCT 116 cells was isolated using the RNeasy Kit (Qiagen) and analyzed using Illumina microarrays (HumanHT-12_V4). Raw data were processed according to the manufacturerâ??s standard procedure and further analyzed using ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-58863 | biostudies-arrayexpress
TranscriptomicsGlobal mRNA expression profiling of HCT116 cells overexpressing miR30a-5p
Global mRNA expression profiling of HCT116 cells overexpressing miR30a-5p were collected using Agilent human whole genome array (G4845A AMADID 026652, cRNA 4x44k V2) . Two different sources of RNA were analyzed: 1.) HCT116 colon cancer cells overexpressing human mir-30a-5p together with a sponge ve...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-29921 | biostudies-arrayexpress
TranscriptomicsInduction of ER stress in HCT116 colon cancer cells
To investigate the role of p53 and DICER in the induction of ER stress, wildtype, p53 knockout or DICER mutant HCT116 colon cancer cells were treated with the ER stress inducers tunicamycin or brefeldin A for 24 hours. Microarray analysis was used to determine changes in gene expression associated w...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-63252 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors
Histone deacetylases (HDACs) regulate gene expression. Inhibition of class I HDACs has been shown to inhibit cancer cell growth. Largazole, a new potent HDAC inhibitor, shows strong antitumor activity, presumably by modulating transcription of cancer relevant genes. We used microarray analysis of hu...
ORGANISM(S): Homo sapiens 
2010-08-28 | E-GEOD-22061 | biostudies-arrayexpress
TranscriptomicsExpression data from HCT116 cells
Advanced colon cancer is characterized by drug resistance and a poor prognosis. In these patients tumor-propagating cells appear to be largely resistant against various targeted drugs including ErbB-inhibitors. The cell surface antigen prominin-1 (CD133) has recently been identified as a potential m...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-38049 | biostudies-arrayexpress
GenomicsChIP-seq for ARID1A in HCT116 cells
This study identifies binding sites for the chromatin remodeller subunit ARID1A in the HCT116 colorectal cancer cell line.
ORGANISM(S): Homo sapiens 
2019-06-24 | E-MTAB-7792 | biostudies-arrayexpress
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