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ProteomicsMolecular insights into RNA polymerase recycling by mycobacterial HelD
Mycobacterial HelD is a transcription factor that binds RNA polymerase (RNAP) and thereby rescues it from stalled transcription complexes. HelD also protects RNAP against the antibiotic rifampicin. HelD, however, must be released from the rescued RNAP to participate in the next round of the transcri...
ORGANISM(S): Mycobacterium smegmatis 
2024-10-08 | PXD046632 | Pride
Held  rna polymerase  mycobacteria  transcription  rifampicin 
ProteomicsCrosslinking/mass spectrometry analysis of Bacillus subtilis RNAP-Delta-HelD complexes
Crosslinking mass spectrometry was applied to investigate protein contacts and dramatic structural rearrangements triggered by HelD binding to RNAP. Four complexes RNAPΔδΔHelD , RNAPΔδΔHelD-δ, RNAPΔδΔHelD-HelD and RNAPΔδΔHelD-δ-HelD were assembled using RNAP purified from B. subtilis ΔhelDΔropE stra...
ORGANISM(S): Cellular Organisms 
2020-10-26 | PXD019437 | JPOST Repository
TranscriptomicsTranscription profiling of Biomphalaria glabrata strains that were resistant or susceptible to Schistosoma mansoni infection, were exposed to the parasite or held unexposed
Snails, either resistant or susceptible to Schistosoma mansoni infection, were exposed to the parasite or held unexposed as controls.
ORGANISM(S): Biomphalaria glabrata 
2009-12-16 | E-MEXP-1882 | biostudies-arrayexpress
UnknownMycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Not available
S-EPMC11464796 | biostudies-literature
ProteomicsBacteria Sense the Antibiotic Rifampicin Through a Widespread Dual-Promoter Based Alarm System
Most antibiotics are natural compounds or their derivatives, and bacteria have evolved defensive mechanisms to resist them. Many of these mechanisms are still poorly understood or uknown. This study reveals that in Bacillus subtilis the transcription factor HelD increases resistance to rifampicin by...
ORGANISM(S): Bacillus subtilis 
2025-12-18 | PXD066046 | Pride
Rna polymerase  held  rifampicin 
UnknownMycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase.
Not available
S-EPMC7749160 | biostudies-literature
UnknownSystematic hand-held echocardiography in patients hospitalized with acute coronary syndrome.
Not available
S-EPMC11441032 | biostudies-literature
UnknownThe neural representation of mental beliefs held by two agents.
Not available
S-EPMC6861364 | biostudies-literature
UnknownCharacterization of HelD, an interacting partner of RNA polymerase from Bacillus subtilis.
Not available
S-EPMC4005671 | biostudies-literature
MetabolomicsTime-dependent stability of plasma and liver interstitial fluid metabolites during sample handling in mice

This study assesses the stability of metabolite levels in plasma and liver interstitial fluid (IF) from mice subjected to different handling times prior to extraction. Blood and tissues from female C57BL/6J mice were collected and either processed immediately or held on ice for 5, 10, or 30 minut...

2025-12-30 | MTBLS13164 | MetaboLights
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