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MetabolomicsSETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia
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ORGANISM(S): Homo sapiens 
ST002323 | MetabolomicsWorkbench
TranscriptomicsGATA-1 and heme regulate the erythroid cell transcriptome.
Alas2 gene encodes the rate-limiting enzyme in heme biosynthesis. CRISPR/Cas9-mediated ablation of two Alas2 intronic cis-elements strongly reduced GATA-1-induced Alas2 transcription, heme biosynthesis, and GATA-1 regulation of other vital constituents of the erythroid cell transcriptome. Bypassing ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-74371 | biostudies-arrayexpress
TranscriptomicsMicrobiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
MetabolomicsBiosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria
A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemica...
2017-07-18 | MTBLS454 | MetaboLights
TranscriptomicsDietary heme alters microbiota and mucosa of mouse colon without functional changes in host-microbe cross-talk.
Colon cancer is a major cause of cancer deaths in Western countries and is associated with diets high in red meat. Heme, the iron-porphyrin pigment of red meat, induces cytotoxicity of gut contents which injures surface cells leading to compensatory hyperproliferation of crypt cells. This hyperproli...
ORGANISM(S): Mus musculus 
2012-12-19 | E-GEOD-40672 | biostudies-arrayexpress
MetabolomicsThe genomic and enzymatic basis for iridoid biosynthesis in cat thyme (Teucrium marum)
Iridoids are non-canonical monoterpenoids produced by both insects and plants. An example is the cat attracting and insect repelling volatile iridoid nepetalactone, produced by Nepeta sp. (catmint) and aphids. Recently, both nepetalactone biosynthetic pathways were elucidated, showing a remarkable c...
2026-04-20 | MTBLS9357 | MetaboLights
TranscriptomicsAedes aegypti (Aag2) Cells: Control (CTR) vs. Heme-incubated / Control vs. Paraquat-incubated
In order to study heme-induced global transcriptional changes, we performed a transcriptome-wide analysis of heme influence on the A. aegypti cell line Aag2. As heme-mediated effects on gene expression are thought to be related to oxidative stress, we compared the transcriptional profiles of Aag2 ce...
ORGANISM(S): Aedes aegypti 
2016-07-29 | E-GEOD-71221 | biostudies-arrayexpress
TranscriptomicsThe two-component system ChrSA is crucial for heme tolerance and interferes with HrrSA in heme-dependent gene regulation in Corynebacterium glutamicum
We recently showed that the two-component system (TCS) HrrSA plays a central role in the control of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum. Here, we characterized the function of another TCS of this organism, ChrSA, which exhibits significant sequence similar...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2012-10-31 | E-GEOD-37327 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in Porphyromonas gingivalis hemH deletion mutant strain grown under heme-depleted conditions (RNA-seq analysis)
Porphyromonas gingivalis, the keystone pathogen responsible for dysbiosis in the oral microbiome, the development of periodontal diseases, and the contribution to systemic comorbidities, is a heme auxotroph. It encodes only four enzymes in the heme biosynthesis pathway, namely HemD, HemN, HemG, and ...
ORGANISM(S): Porphyromonas gingivalis 
2026-03-03 | E-MTAB-16130 | biostudies-arrayexpress
MetabolomicsM3-Driven Hexosamine Biosynthesis Facilitates Hepatocellular Carcinoma Progression through YBX1 O-GlcNAcylation
Phosphoglucomutase 3 (PGM3) is one of the rate-limiting enzymes in the hexosamine biosynthesis pathway (HBP) and a key regulator of HBP metabolic flux. Despite the functional role of PGM3 has been validated in various tumors, its function and molecular mechanism in hepatocellular carcinoma (HCC) rem...
2026-09-04 | MTBLS15552 | MetaboLights
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