Sort   by:  
 Page size 
MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
ProteomicsMalaria parasites require a divergent heme oxygenase for apicoplast biogenesis
Affinity purification data for Heme Oxygenase from Plasmodium falciparum
ORGANISM(S): Plasmodium Falciparum (ncbitaxon:5833) 
2024-05-06 | MSV000094692 | MassIVE
ProteomicsThe heme regulatory motifs of heme oxygenase-2 function to transfer heme to the catalytic site for degradation
Heme regulatory motifs (HRMs) are found in a variety of proteins that are involved in diverse biological functions. In the C-terminal tail region of human heme oxygenase-2 (HO2), there are two HRMs whose cysteines form a disulfide bond; when reduced, these cysteines are available to bind Fe3+-heme. ...
ORGANISM(S): Homo sapiens (Human) 
2020-03-18 | PXD017538 | Pride
Enzyme mechanisms  enzyme kinetics  protein dynamics  conformational change  hydrogen deuterium exchange  hdxms 
TranscriptomicsGene expression data of endothelium exposed to heme
Sickle cell disease is characterized by hemolysis, vaso-occlusion and ischemia reperfusion injury. These events cause endothelial dysfunction and vasculopathies in multiple systems However, the lack of atherosclerotic lesions has led to the idea that there are adaptive mechanisms that protect the en...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-25014 | biostudies-arrayexpress
TranscriptomicsInhibition of dendritic cell maturation and effector function
The initiation of donor derived dendritic cell (DC) adhesion and migration are one of the key events mediated by ischemia reperfusion injury (IRI) following solid organ transplantation. Recently we have been able to demonstrate that a single donor treatment with the synthetic metalloporphyrin cobalt...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-8452 | biostudies-arrayexpress
MetabolomicsRecombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle
The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor BVIX yields (<0.05%), and is not conducive to scalab...
2021-12-16 | MTBLS3555 | MetaboLights
TranscriptomicsThe two-component system ChrSA is crucial for heme tolerance and interferes with HrrSA in heme-dependent gene regulation in Corynebacterium glutamicum
We recently showed that the two-component system (TCS) HrrSA plays a central role in the control of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum. Here, we characterized the function of another TCS of this organism, ChrSA, which exhibits significant sequence similar...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2012-10-31 | E-GEOD-37327 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human trophoblast cells isolated from first trimester human placentae and villous explant cultures
Invasion of cytotrophoblasts into uterine tissues is essential for placental development. To identify molecules regulating trophoblast invasion, mRNA signatures of purified villous (CTB, poor invasiveness) and extravillous (EVT, high invasiveness) trophoblasts isolated from first trimester human pla...
ORGANISM(S): Homo sapiens 
2009-01-30 | E-GEOD-9773 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of caffeic acid phenethyl ester-treated human umbilical vein endothelial cells-1
Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion (I/R) injury in vivo, and this has been attributed to its ability to reduce the oxidative stress. Here we investigated the cytoprotection of CAPE against menadione (MD)-induced ...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10413 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of caffeic acid phenethyl ester-treated human umbilical vein endothelial cells-2
Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion (I/R) injury in vivo, and this has been attributed to its ability to reduce the oxidative stress. Here we investigated the cytoprotection of CAPE against menadione (MD)-induced ...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10429 | biostudies-arrayexpress
Sort   by:  
 Page size