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MetabolomicsIntegrated multi-omics analysis of liver metabolic dysregulation in ACE2 knockout mice
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
2025-06-23 | MTBLS12389 | MetaboLights
ProteomicsIncreased Basal MET phosphorylation is a Hallmark of Hepatocyte Dysregulation in Liver Disease: Mouse
Non-alcoholic fatty liver disease (NAFLD) is gaining evermore importance due to rapidly rising incidence rates especially in western countries. As the disease progresses, it can develop into hepatocellular carcinoma. Related metabolic changes have been extensively studied in the past. However, the m...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-15 | PXD041563 | Pride
Western diet  dynamic pathway modeling  hepatocyte dysregulation  fatty liver disease  hgf signal transduction 
MetabolomicsComparative 1H-NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases associated with increased cardiovascular risk and metabolic alterations. We applied 1H-NMR spectroscopy to profile lipoproteins and metabolites in women with RA, SLE, and healthy controls. Both RA an...

2026-02-02 | MTBLS13820 | MetaboLights
ProteomicsIncreased Basal MET phosphorylation is a Hallmark of Hepatocyte Dysregulation in Liver Disease: Human
Non-alcoholic fatty liver disease (NAFLD) is gaining evermore importance due to rapidly rising incidence rates especially in western countries. As the disease progresses, it can develop into hepatocellular carcinoma. Related metabolic changes have been extensively studied in the past. However, the m...
ORGANISM(S): Homo sapiens (Human) 
2024-01-15 | PXD043007 | Pride
Liver Primary hepatocytes Fatty liver 
ProteomicsAlcohol-associated hepatitis induces hepatocyte senescence which is reduced following disease resolution
Background & Aims: Alcohol-associated hepatitis (AH) is an acute form of alcohol-related liver disease (ArLD) with high mortality rate. AH is histologically characterised by cellular processes including steatosis, inflammation and cell death. Apoptosis is the most studied form of cell death in AH; h...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD053109 | Pride
Liver Hepatocyte Alcohol 
ProteomicsIntegrated multi-omics analysis of liver metabolic dysregulation in ACE2 knockout mice
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-23 | PXD063359 | Pride
Angiotensin-converting enzyme 2 (ace2) Gene knockout (ko) Liver metabolic dysregulation 
UnknownHepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice.
Not available
S-EPMC8884714 | biostudies-literature
GenomicsHepatocyte polyploidization during ageing protects against transcriptional dysregulation and chronic liver disease
Hepatocyte polyploidization during ageing protects against transcriptional dysregulation and chronic liver disease
PRJEB64026 | ENA
GenomicsHepatocyte Hedgehog Signaling Controls Ferroptosis to Alleviate Aging-related Organ Dysfunction
Hepatocyte Hedgehog Signaling Controls Ferroptosis to Alleviate Aging-related Organ Dysfunction
PRJNA1463256 | ENA
UnknownHuman iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity.
Not available
S-EPMC9780780 | biostudies-literature
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