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MetabolomicsZingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of Sat1 and Gpx4 expression

Zingerone, a component of dried ginger, has known anti-ulcer and bone growth-promoting effects, but its impact on postmenopausal osteoporosis (PO) is unclear. This study investigates the therapeutic potential and underlying mechanisms of zingerone in PO. A concentration-dependent effect identifie...

2025-08-07 | MTBLS12829 | MetaboLights
MetabolomicsGlutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1-mediated metabolic reprogramming
This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a glutamine-restricted diet not only reverses KRASG12D inhibitor resistance in PDAC but also achieves durable remission with long-term...
2026-06-27 | MTBLS14825 | MetaboLights
MetabolomicsTiming of unsaturated fat intake improves insulin sensitivity through gut microbiota-dependent regulation of bile acid metabolism: a randomized controlled trial

The timing of dietary fat intake influences metabolic health. However, the impact of the timing of unsaturated fat (USFA) intake on glycemic control has yet to be explored. This 12-week, double-blind, randomized, controlled, 2 x 2 factorial-designed feeding trial investigated the effects of timin...

2025-04-14 | MTBLS12353 | MetaboLights
MetabolomicsComprehensive High-Resolution Multiple-Reaction Monitoring Mass Spectrometry for Targeted Eicosanoid Assays
Eicosanoids comprise a class of bioactive lipids derived from a unique group of essential fatty acids that mediate a variety of important physiological functions. Owing to the structural diversity of these lipids, their analysis in biological samples is often a major challenge. Advancements in mass ...
2018-06-26 | MTBLS641 | MetaboLights
MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS positive mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7711 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7713 | MetaboLights
MetabolomicsSystem-wide analysis of short-term response to high temperature in Pinus radiata

Pinus radiata seedlings, the most widely planted pine species in the world, were exposed to temperatures within a range mimicking future scenarios based on current models of heat increase. The short-term heat response in P. radiata was studied in detail by exploring the metabolo...

2023-08-14 | MTBLS4567 | MetaboLights
ProteomicsTwo-step peptide solubilization increases coverage in high-sensitivity nanoHILIC/MS/MS-based proteomics
Nanoscale hydrophilic-interaction chromatography coupled with tandem mass spectrometry (nanoHILIC/MS/MS) is a promising alternative to reversed-phase liquid chromatography (RPLC) for proteomics, but its application is limited by the poor solubility of peptides in organic solvent-rich sample solution...
ORGANISM(S): Homo Sapiens (human) Bos Taurus 
2025-05-08 | PXD059304 | JPOST Repository
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
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