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MetabolomicsProfile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C
Vitamin C (Ascorbic acid, AA), as vital micro-nutrient, plays an essential role for male animal reproduction. Previously, we showed that vitamin C reprogrammed the transcriptome and proteome to change phenotypes of porcine immature Sertoli cells (iSCs). Here, we used LC-MS-based non-targeted metabol...
2024-07-31 | MTBLS9673 | MetaboLights
ProteomicsRPL6 interacts with HMGCS1 to stabilize HIF-1α by promoting cholesterol production in hepatocellular carcinoma.
The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary met...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD064850 | Pride
Hepatocellular carcinoma  metastasis  rpl6  hmgcs1  cholesterol 
ProteomicsRPL6 interacts with HMGCS1 to stabilize HIF-1α by activating cholesterol biosynthesis in hepatocellular carcinoma.
The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary met...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD054740 | Pride
Hepatocellular carcinoma  metastasis  rpl6  hmgcs1  cholesterol 
GenomicsUnconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases
Unconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases
PRJNA1310542 | ENA
GenomicsUnconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases II
Unconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases II
PRJNA1315254 | ENA
UnknownTargeting HMGCS1 restores chemotherapy sensitivity in acute myeloid leukemia.
Not available
S-EPMC11239175 | biostudies-literature
GenomicsUnconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases [scRNA-seq]
Unconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases [scRNA-seq]
PRJNA1312097 | ENA
TranscriptomicsUnconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases
Identifying factors controlling pathogenic-Th17 cells is of importance, for their vital role in inflammation and immune-pathology. While intricate ER stress signals have been implicated in T cell biology, its role in Th17 cells remain poorly understood. Here, we demonstrated that HMGCS1, a cholester...
ORGANISM(S): Mus musculus 
2026-03-18 | GSE306371 | GEO
TranscriptomicsUnconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases II
Identifying factors controlling pathogenic-Th17 cells is of importance, for their vital role in inflammation and immune-pathology. While intricate ER stress signals have been implicated in T cell biology, its role in Th17 cells remain poorly understood. Here, we demonstrated that HMGCS1, a cholester...
ORGANISM(S): Mus musculus 
2026-03-18 | GSE307331 | GEO
TranscriptomicsUnconventional role of HMGCS1 in driving pathogenic-Th17 cell immunity and autoimmune diseases [scRNA-seq]
Identifying factors controlling pathogenic-Th17 cells is of importance, for their vital role in inflammation and immune-pathology. While intricate ER stress signals have been implicated in T cell biology, its role in Th17 cells remain poorly understood. Here, we demonstrated that HMGCS1, a cholester...
ORGANISM(S): Mus musculus 
2026-03-18 | GSE306780 | GEO
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