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MetabolomicsMulti-omics profiling identifies MAPK signaling suppression associated with tetracycline-induced root toxicity in soybean
Tetracycline (TC), a widely used veterinary antibiotic, is a pervasive emerging contaminant threatening crop production. Here, we employed integrated physiological, metabolomic, and transcriptomic analyses to decipher the response of soybean (Glycine max L.) to TC. While seed germination was unaffec...
2026-09-07 | MTBLS15077 | MetaboLights
MetabolomicsLimited survival and impaired hepatic fasting metabolism of glucose, amino acids and lipids in mice with constitutive Rag GTPase signaling
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (RagAGTP) in mice resulted in a fatal energetic crisis...
2021-05-11 | MTBLS2397 | MetaboLights
MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
ProteomicsS-nitrosation of SCF E3 ligase components regulates hormonal signaling in Arabidopsis
E3 ubiquitin ligases mediate the last step of the ubiquitination pathwayin the ubiquitin-proteasome system (UPS). By targeting transcriptional regulators for their turnover, E3s play a crucial role in every aspect of plant biology. In plants, SKP1/CULLIN1/F-BOX PROTEIN (SCF)-type E3 ubiquitin ligase...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-04-04 | PXD030054 | Pride
S-nitrosation  hormonal signaling  arabidopsis 
TranscriptomicsCryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling
This study was designed to provide additional insight into testicular hormone production and responsiveness in the orl strain and complement ongoing efforts to characterize the genetic basis of cryptorchidism in this isolated rat colony. Gubernacula were harvested from Long Evans and ORL rat embryos...
ORGANISM(S): Rattus norvegicus 
2014-07-02 | E-GEOD-57924 | biostudies-arrayexpress
GenomicsInteractions of ARF6 with PIF4, BZR1, and RGA integrate auxin signaling with environmental and other hormonal signals in Arabidopsis [ChIP-Seq]
Auxin is a major plant hormone for both development and environmental adaptation. Auxin responses are context dependent and highly modulated by light, temperature, the circadian clock, brassinosteroid, and gibberellin, but the underlying mechanisms remain unclear. Here, we show that auxin signaling ...
ORGANISM(S): Arabidopsis thaliana 
2014-06-03 | E-GEOD-51770 | biostudies-arrayexpress
TranscriptomicsInteractions of ARF6 with PIF4, BZR1, and RGA integrate auxin signaling with environmental and other hormonal signals in Arabidopsis [RNA-Seq]
Auxin is a major plant hormone for both development and environmental adaptation. Auxin responses are context dependent and highly modulated by light, temperature, the circadian clock, brassinosteroid, and gibberellin, but the underlying mechanisms remain unclear. Here, we show that auxin signaling ...
ORGANISM(S): Arabidopsis thaliana 
2014-06-03 | E-GEOD-51772 | biostudies-arrayexpress
GenomicsAcute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [PRO-seq mouse]
Acute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [PRO-seq mouse]
PRJNA1284852 | ENA
GenomicsAcute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [CUT&Run mouse]
Acute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [CUT&Run mouse]
PRJNA1284847 | ENA
GenomicsTriploidy disrupts hormonal and paracrine signaling and enforces male development in zebrafish
Triploidy disrupts hormonal and paracrine signaling and enforces male development in zebrafish
PRJNA1311497 | ENA
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