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ProteomicsMethionine Restriction Alleviates Kidney Fibrosis through Epigenetic Repression of the TGF-β-Smad3-Hoxc8/P-TEFb axis
Low-protein diets can mitigate renal fibrosis, yet the critical amino acid responsible for this benefit and its underlying mechanism remain unclear. By screening 15 amino acid–restricted diets in a unilateral ureteral obstruction (UUO) model, we identify methionine restriction (MetR) as the most eff...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD071531 | Pride
Kidney fibrosis  methionine restriction  hoxc8  p-tefb 
GenomicsTranscriptome analysis of gene expression in A549 cell by Regulation of HOXC8 expression
Transcriptome analysis of gene expression in A549 cell by Regulation of HOXC8 expression
PRJNA552545 | ENA
TranscriptomicsExpression analysis of human adipose tissue stem cells (ADSCs) transduced with homeobox C8 (Hoxc8) or control vector, followed by treatment with adipogenic-induction media for 14 days
Adipogenesis occurs through a specific gene program in undifferentiated fat progenitors. We hypothesized that the properties of the fat progenitors are regulated by hox genes, the developmental genes essential in different tissue stem cells. Their biased expression in white and brown fat implies rol...
ORGANISM(S): Homo sapiens 
2010-06-18 | E-GEOD-22429 | biostudies-arrayexpress
UnknownThe identification of Hoxc8 target genes.
Not available
S-EPMC549016 | biostudies-literature
GenomicsNew roles for Hoxc8 in the establishment and maintenance of motor neuron identity
New roles for Hoxc8 in the establishment and maintenance of motor neuron identity
PRJNA731166 | ENA
UnknownHOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.
Not available
S-EPMC4058030 | biostudies-literature
UnknownEffects of HOXC8 on the Proliferation and Differentiation of Porcine Preadipocytes.
Not available
S-EPMC10451666 | biostudies-literature
GenomicsMethionine Restriction Alleviates Kidney Fibrosis through Epigenetic Repression of the TGF-β/Smad3/Hoxc8/P-TEFb Axis
Methionine Restriction Alleviates Kidney Fibrosis through Epigenetic Repression of the TGF-β/Smad3/Hoxc8/P-TEFb Axis
PRJNA1211161 | ENA
TranscriptomicsMethionine Restriction Alleviates Kidney Fibrosis through Epigenetic Repression of the TGF-β/Smad3/Hoxc8/P-TEFb Axis
Renal fibrosis is a hallmark of chronic kidney diseases (CKDs) and a key driver of disease progression. While low-protein diets have been shown to alleviate fibrosis and slow CKD progression, the specific amino acids responsible for these effects remain unclear, and such diets often lead to malnutri...
ORGANISM(S): Rattus norvegicus 
2025-12-04 | GSE287134 | GEO
TranscriptomicsOverexpression of Hoxc8 transcription factor alters transcriptional profiles in mouse chondrocytes at E18.5
Homeobox genes of the Hox class are required for proper patterning of skeletal elements and play a role in cartilage differentiation. In transgenic mice with overexpression of Hoxc8 during cartilage development, we observed severe defects, namely physical instability of cartilage, accumulation of im...
ORGANISM(S): Mus musculus 
2010-10-15 | E-GEOD-18992 | biostudies-arrayexpress
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