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ProteomicsHsp90i resistance - Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
The goal is to describe the mechanisms underlying the resistance of melanoma against Hsp90i using (phospho)proteomics
ORGANISM(S): Homo sapiens (Human) 
2018-02-26 | PXD005518 | Pride
Proteomics  phosphoproteomics  lc/ms/ms  hsp90i 
GenomicsTranscriptomic analysis of Hsp90 inhibitor (Hsp90i)-treated HIV-infected pediatric tonsillar mononuclear cells
Transcriptomic analysis of Hsp90 inhibitor (Hsp90i)-treated HIV-infected pediatric tonsillar mononuclear cells
PRJNA737514 | ENA
TranscriptomicsTranscriptomic analysis of Hsp90 inhibitor (Hsp90i)-treated HIV-infected pediatric tonsillar mononuclear cells
Purpose: Hsp90 is a host chaperone protein that regulates cellular homeostasis by interacting with a diverse clientele of cellular proteins. Several of these proteins are involved in cellular pathways that play crucial roles in facilitating HIV replication. Identification of key cellular genes that ...
ORGANISM(S): Homo sapiens 
2024-06-14 | GSE178178 | GEO
ProteomicsCETSA Hsp90i - Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
The goal of this project is to identify the drug target of XL888, an hsp90i used in clinical trial against melanoma
ORGANISM(S): Homo sapiens (Human) 
2018-02-13 | PXD005508 | Pride
Cetsa-ms  brp  lc/ms/ms 
TranscriptomicsLoss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors
Heat Shock Protein 90 inhibitors (HSP90i) have shown encouraging activity in EML4-ALK+ non-small cell lung cancer (NSCLC) patients but clinical responses have been heterogeneous. It has been suggested that distinct EML4-ALK variants may have a differential impact on the response to HSP90 inhibition....
ORGANISM(S): Homo sapiens 
2025-02-01 | GSE197655 | GEO
TranscriptomicsDecrypting the role of HSP90α and β isoforms to overcome resistance in BCR-ABL1+ leukemia
BCR-ABL1+ leukemia entity still is associated with poor prognosis and new therapies are urgently needed. Heat shock proteins of 90 kDa (HSP90) have been widely studied due to their chaperone function, implicated in stabilizing various oncoproteins, including BCR-ABL1 kinase. However, HSP90 inhibitor...
ORGANISM(S): Homo sapiens 
2022-07-19 | GSE208005 | GEO
UnknownOvercoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.
Not available
S-EPMC6345040 | biostudies-literature
UnknownActivity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation.
Not available
S-EPMC6093313 | biostudies-literature
UnknownConsecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors.
Not available
S-EPMC6696991 | biostudies-literature
UnknownA Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition.
Not available
S-EPMC6942625 | biostudies-literature
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