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MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
TranscriptomicsTranscriptomic profiling of patient-derived endometrial cancer organoids (Berg HF)
Patient-derived endometrial cancer organoids. The data was used to compare gene expression profile between organoids, and to explore whether an organoid-derived gene signature could predict disease outcomes in independent patient cohorts.
ORGANISM(S): Homo sapiens 
2021-07-16 | E-MTAB-10664 | biostudies-arrayexpress
TranscriptomicsMenstrual flow as a non-invasive source of endometrial organoids
Organoid cultures derived from menstrual flow faithfully replicate secretory phase endometrial glands and provide a novel, non-invasive technique for the clinical assessment of endometrial function. Paired organoid cultures derived from scratch biopsies and ensuing menstrual flow share the same tran...
ORGANISM(S): Homo sapiens 
2021-04-13 | E-MTAB-9284 | biostudies-arrayexpress
ProteomicsIntegrated microRNA and secretome analysis of human endometrial organoid reveal the miR-3194-5p/Aquaporin/S100A9 module in regulating trophoblast functions
Successful placentation requires delicate communication between endometrium and trophoblasts. The invasion and integration of trophoblasts into the endometrium during early pregnancy is crucial to placentation. Dysregulation of these functions is associated with various pregnancy complications such ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD036535 | Pride
Secretome  human endometrial organoid  itraq  lc-ms/ms 
TranscriptomicsSingle-cell RNA-seq of Endometrial organoids treated with NOTCH or WNT inhibitors in a time course of Estrogen and Progesterone stimulation
We performed single-cell RNA-sequencing of 3D endometrial organoid cultures in order to dissect the signaling pathways that determine cell fate of epithelial lineages. Every time course was obtained in a background that either included or did not include ovarian hormones stimulation, which emulates ...
ORGANISM(S): Homo sapiens 
2021-07-21 | E-MTAB-10283 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of healthy versus cystic fibrosis human endometrial organoids upon hormonal exposure
Female cystic fibrosis (CF) patients are confronted with fertility deficiency, experiencing difficulties in getting pregnant. Underlying reasons remain elusive. In particular, it has only poorly been studied whether the endometrium, the inner lining of the womb and crucial tissue for embryo implanta...
ORGANISM(S): Homo sapiens 
2025-04-08 | E-MTAB-14456 | biostudies-arrayexpress
GenomicsCapture and metabolomic analysis of the human endometrial epithelial organoid secretome
Capture and metabolomic analysis of the human endometrial epithelial organoid secretome
PRJNA700066 | ENA
TranscriptomicsTranscriptomic profiling of endometrial primary tumors
Fresh tumor tissue from primary endometrial tumors. Technology: L1000 is an array based technology that measured 978 landmark genes that are extrapolated using an algorithm to generate a transcription profile of 12,328 genes. Reference L1000 technology: Subramanian A, et al. A Next Generation Conne...
ORGANISM(S): Homo sapiens 
2021-07-06 | E-MTAB-10668 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of endometrial organoids in the IVMC protocol
Accessing endometrial tissue during the early phases of the menstrual cycle is challenging. With this experiment we are capturing the dynamic epithelial cell states after breakdown using endometrial organoids (EOs) subjected to the in vitro menstrual cycle (IVMC) protocol. EOs are collected for scRN...
ORGANISM(S): Homo sapiens 
2026-04-28 | E-MTAB-15330 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Pluripotent Stem Cell-Derived Endometrial Stromal Fibroblasts in Monolayer Differentiation and in Co-culture with Endometrial Epithelial Organoids
H9 Pluripotent Stem Cells (PSC) were differentiated to Endometrial Stromal Fibroblasts (PSC-ESF) in monolayer over the course of 12 days. Gene expression was measured at day 0, day 4, day 8, and day 12 of differentiation. At day 12, PSC-ESF were dissociated from monolayer culture for co-culture with...
ORGANISM(S): Homo sapiens 
2021-05-05 | E-MTAB-10375 | biostudies-arrayexpress
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