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MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
ProteomicsGlobal Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identifies Hyperacetylation of PKM2 as a Metabolic Reg-ulator in Sepsis
Sepsis-induced liver dysfunction is a frequent event and is strongly associated with mortality. Establishing a causative link between protein post-translational modification (PTM) and diseases is challenging. We studied the relationship among the lysine acetylation (Kac), the sirtuin (SIRTs), and th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-30 | PXD027496 | Pride
Sepsis-induced liver dysfunction  hyperacetylation  sirt  lysine acetylation  pyruvate kinase m2 
GenomicsGenomic topography of HDACi-induced hyperacetylation of hippocampal chromatin [ChIP-Seq]
Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory and synaptic plasticity and to ameliorate cognitive deficits and degeneration in animal models for different neuropsychiatric conditions. However, the impact of these drugs on hippocampal histone acety...
ORGANISM(S): Mus musculus 
2013-07-09 | E-GEOD-43439 | biostudies-arrayexpress
ProteomicsMitochondrial Protein Hyperacetylation in the Failing Heart
Mitochondrial proteomics was used to identify energy metabolic derangements that occur during the early stages of heart failure in well-defined mouse models. Levels of β-hydroxybutyrate dehydrogenase 1 (BDH1), a key enzyme in ketone oxidation, was upregulated. 13C-substrate flux studies and metabol...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-26 | PXD001652 | Pride
Heart failure Acetylation Mitochondria 
GenomicsARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_P300_ChIP)
ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_P300_ChIP)
PRJNA624336 | ENA
GenomicsARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (P300_ChIP)
ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (P300_ChIP)
PRJNA624337 | ENA
GenomicsARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_H3K4me1_ChIP)
ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_H3K4me1_ChIP)
PRJNA662588 | ENA
GenomicsARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_H3K4me3_H3K27me3_ChIP)
ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_H3K4me3_H3K27me3_ChIP)
PRJNA662590 | ENA
GenomicsARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_H3K27ac_CUTNRUN)
ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (diff_H3K27ac_CUTNRUN)
PRJNA662587 | ENA
GenomicsARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (RNA)
ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation (RNA)
PRJNA624334 | ENA
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