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ProteomicsSmall Extracellular Vesicles derived from four dimensional-culture of mesenchymal stem cells induce alternatively activated macrophages by upregulating IGFBP2/EGFR to attenuate inflammation in the spinal cord injury of rats
Effectively reducing the inflammatory response after spinal cord injury (SCI) is a challenging clinical problem and the subject of active investigation. This study employed a porous scaffold-based three dimensional long-term culture technique to obtain human umbilical cord mesenchymal stem cell (hUC...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040516 | Pride
Spinal cord injury  small extracellular vesicles  four dimensional culture  macrophage polarization  igfbp2/egfr 
UnknownIGFBP2 potentiates nuclear EGFR-STAT3 signaling.
Not available
S-EPMC4615268 | biostudies-literature
UnknownIGFBP2 functions as an endogenous protector against hepatic steatosis via suppression of the EGFR-STAT3 pathway.
Not available
S-EPMC11474195 | biostudies-literature
UnknownIGFBP2 regulates PD-L1 expression by activating the EGFR-STAT3 signaling pathway in malignant melanoma.
Not available
S-EPMC7816098 | biostudies-literature
UnknownActivation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage.
Not available
S-EPMC6327430 | biostudies-literature
UnknownNIPA1 depletion in tumor-associated macrophages via IGFBP2/EGFR attenuates acute myeloid leukemia progression and chemoresistance.
Not available
S-EPMC12619713 | biostudies-literature
UnknownSmall extracellular vesicles derived from four dimensional-culture of mesenchymal stem cells induce alternatively activated macrophages by upregulating IGFBP2/EGFR to attenuate inflammation in the spinal cord injury of rats.
Not available
S-EPMC10176095 | biostudies-literature
TranscriptomicsTranscription profiling of human high grade gliomas with a 1p19q codeletion or with EGRF amplification
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We performed a microarray gene expr...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-MEXP-1507 | biostudies-arrayexpress
TranscriptomicsSingle cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer
We investigate non-genomic mechanisms determining cellular response to EGFR inhibitors in triple negative breast cancer (TNBC). We integrate methods for cellular barcoding and single-cell transcriptomics to enable cell lineage tracing and explore the subclonal evolution of adaptation in an establish...
ORGANISM(S): Homo sapiens 
2024-03-25 | GSE228154 | GEO
UnknownIGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.
Not available
S-EPMC11199710 | biostudies-literature
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