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Human PI3KGamma deficiency with immunodeficiency and tissue immunopathology
Human PI3KGamma deficiency with immunodeficiency and tissue immunopathology
CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. Here we evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningi...
ORGANISM(S): Mus musculus 
Clinically, obesity is strongly associated with severe TH2 immunopathology, though the physiological, cellular, and molecular underpinnings of this association remain obscure. We demonstrate that obese mice are susceptible to severe atopic dermatitis (AD), a major manifestation of TH2 immunopatholog...
ORGANISM(S): Mus musculus 
2022-03-29 | GSE189216 | GEO
ADAR1 mutation causes ZBP1-dependent immunopathology

Whole exome sequencing of a trio (parents and offspring) reveals PIK3CG mutations that result in loss of protein in the child with immunodeficiency and immunopathology.

ADAR1 mutation causes ZBP1-dependent immunopathology II
ADAR1 mutation causes ZBP1-dependent immunopathology I
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