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Metabolomics1H NMR Metabolomics Reveals Association of High Expression of Inositol 1, 4, 5 Trisphosphate Receptor and Metabolites in Breast Cancer Patients
1H NMR is used to detect alterations in metabolites and their linkage to metabolic processes in a number of pathological conditions including breast cancer. Inositol 1, 4, 5 trisphosphate (IP3R) receptor is an intracellular calcium channel known to regulate metabolism and cellular bioenergetics. Its...
2017-07-18 | MTBLS326 | MetaboLights
MetabolomicsMetabolomics study for investigating the specific role of INOSITOL-REQUIRING ENZYME 1A and INOSITOL-REQUIRING ENZYME 1B under chronic endoplasmic reticulum stress in Arabidopsis thaliana

The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This metabolomic dataset was produced from 14-day-old Arabidopsis thaliana s...

2024-12-02 | MTBLS10609 | MetaboLights
MetabolomicsInositol Pyrophosphates Mediate Chloroplast Lipid Remodeling and Nuclear Gene Repression during High-Light Acclimation in Chlamydomonas reinhardtii
Microalgae are photosynthetic organisms capable of autotrophic growth. Their applicability in multiple industrial fields has been largely studied, thanks to their ability to fixate CO2 into high added value organic products like fatty acids and carotenoids. However, our under-standing of the cellula...
2026-06-09 | MTBLS14720 | MetaboLights
MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
MetabolomicsInositol polyphosphates regulate resilient mechanisms in the green alga Chlamydomonas reinhardtii to adapt to extreme nutrient conditions

In the actual context of climate changing environments, photosynthetic organisms need to adapt to more extreme conditions. Microalgae can be excellent organisms to understand molecular mechanisms that activate survival mechanisms under stress. Chlamydomonas reinhardtii signaling mutants are extre...

2024-12-05 | MTBLS10779 | MetaboLights
TranscriptomicsIntegrated analysis of the transcriptome-lipidome reveals the interactions of inositol-choline and SNF1 in controlling lipid biosynthesis
Characterize the transcriptional response to inositol-choline and snf1 We used microarrays to capture the global responses of inositol-choline concentration and snf deletion in Carbon and Nitrogen limited growth
ORGANISM(S): Saccharomyces cerevisiae 
2012-08-29 | E-GEOD-32418 | biostudies-arrayexpress
TranscriptomicsIpsA, a novel transcriptional regulator required for inositol derived lipid formation in Corynebacteria and Mycobacteria
The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well unde...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-01-13 | E-GEOD-50210 | biostudies-arrayexpress
TranscriptomicsConcerted action of Helios and Ikaros balances the strength of B cell receptor signaling and controls the expression of inositol 5-phosphatase SHIP
Inositol 5-phosphatase SHIP is differentially expressed in Ikaros and Helios deficient cells. In the absense of Ikaros SHIP is upregulated where as in the absense of Helios it is downregulated. Ikaros binds to the promoter of the SHIP gene. Article provides insight into the mechanisms of action Ikar...
ORGANISM(S): Gallus gallus 
2010-07-19 | E-GEOD-20946 | biostudies-arrayexpress
TranscriptomicsCaulobacter vibrioides CB15N mRNA expression in M2-Glucose Vs. M2-Inositol
The purpose of this experiment was to examine the differential transcriptional profiles of Caulobacter CB15N grown in M2-Glucose versus M2-Inositol. mRNA expression was compared between Caulobacter CB15N cells grown in M2-Glucose vs. M2-Inositol. Four arrays were run, two of each dye combination.
ORGANISM(S): Caulobacter vibrioides 
2010-06-30 | E-GEOD-12414 | biostudies-arrayexpress
TranscriptomicsInositol regulation with Cryptococcus neoformans JEC21 70-mer whole genome array
Cryptococcus neoformans is the most common cause of fungal meningitis, with high mortality and morbidity. The reason for the frequent occurrence of Cryptococcus infection in the central nervous system (CNS) is poorly understood. In this study, we find that inositol plays an important role in the tra...
ORGANISM(S): Cryptococcus neoformans 
2012-09-29 | E-GEOD-41211 | biostudies-arrayexpress
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