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MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
MetabolomicsClostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation

The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection re...

2023-05-30 | MTBLS4590 | MetaboLights
Proteomicsinterferon-induced global cellular SUMOylation Changes
This proteomics dataset was generated to study the changes in SUMO site abundances between control cells and Interferon-alpha treated cells using SILAC. Cells were first fractionated into the cytoplasmic and nuclear fractions. SUMOylated proteins were then purified from these extracts by Ni-NTA via ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081525 | MassIVE
ProteomicsInterferon Regulatory Factors: IRF1 and IRF7 directly regulate gene expression in bats in response to viral infection.
Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with IFNα signalling. Here we show IRF1,3 and 7 levels are elevated in most bat tissues and that basally, IRFs contribute to the expression of type I IFN ligands and high expression of Interferon Regula...
ORGANISM(S): Cellular Organisms 
2020-10-23 | PXD021982 | JPOST Repository
TranscriptomicsTranscription profiling of human bronchial epithelial cells treated with interferon gamma and/or dexamethasone
RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1815 | biostudies-arrayexpress
TranscriptomicsInterferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier
Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress
TranscriptomicsExpression data from primary human dermal fibroblasts with STAT2 deficiency and control fibroblasts treated with interferon
Primary human dermal fibroblasts were isolated from an individual showing a genetic defect in innate antiviral immunity associated with profound failure of type 1 interferon signaling and absence of the STAT2 protein. The transcriptional response of these cells to a 10h treatment with interferon-alp...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-41960 | biostudies-arrayexpress
TranscriptomicsTimecourse of Interferon-Gamma Treatment of Bone Marrow-Derived Macrophages (BMDMs)
The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma (IFN-g)) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the p...
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-42504 | biostudies-arrayexpress
TranscriptomicsInflammasome-dependent Interferon-gamma drives pathogenesis in Streptococcus pneumoniae meningitis.
A comparison of brain gene expression profiles in wildtype mice and interferon gamma -/- mice during bacterial meningitis.
ORGANISM(S): Mus musculus 
2012-09-01 | E-MEXP-3697 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human macrophages from ankylosing spondylitis patients reveals interferon-gamma dysregulation
OBJECTIVE: To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern. METHODS: Macrophages were derived from the peripheral blood of 8 AS patients (median disease duration 13 years [range <1-43 yea...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11886 | biostudies-arrayexpress
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