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GenomicsInterleukin-36 upregulated type-I interferon responses in systemic lupus erythematosis by promoting the accumulation of self-nucleic acids
Interleukin-36 upregulated type-I interferon responses in systemic lupus erythematosis by promoting the accumulation of self-nucleic acids
PRJNA1389013 | ENA
TranscriptomicsInterleukin-36 upregulated type-I interferon responses in systemic lupus erythematosis by promoting the accumulation of self-nucleic acids
Several studies have reported an up-regulation of interleukin (IL)-36 in the serum of patients with systemic lupus erythematosus (SLE). Here, we sought to define the mechanisms whereby IL-36 may contribute to the over-activation of type I Interferon (IFN) responses observed in SLE. We carried out si...
ORGANISM(S): Homo sapiens 
2026-03-12 | GSE314010 | GEO
UnknownRole of Interleukin 36 in Generalised Pustular Psoriasis and Beyond.
Not available
S-EPMC8850521 | biostudies-literature
UnknownStructural and Functional Attributes of the Interleukin-36 Receptor.
Not available
S-EPMC4974375 | biostudies-literature
GenomicsTranscriptional profiling of long-term stimulated primary murine intestinal fibroblasts with interleukin-36.
Transcriptional profiling of long-term stimulated primary murine intestinal fibroblasts with interleukin-36.
PRJEB24922 | ENA
UnknownInterleukin-36 Cytokine/Receptor Signaling: A New Target for Tissue Fibrosis.
Not available
S-EPMC7556029 | biostudies-literature
TranscriptomicsTranscriptional profiling of long-term stimulated primary murine intestinal fibroblasts with interleukin-36.
Previous stimulation experiments of stimulated primary murine colonic fibroblasts with IL-36R ligands for 4h in vitro showed an upregulation of pro-inflammatory cytokines e.g. IL-6, IL-1b and chemokines e.g. CXCL1, CCL2 indicating an important role for IL-36 in inflammation. We were interested in an...
ORGANISM(S): Mus musculus 
2018-11-19 | E-MTAB-6476 | biostudies-arrayexpress
UnknownDiscovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies.
Not available
S-EPMC11829961 | biostudies-literature
UnknownInterleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis.
Not available
S-EPMC10717293 | biostudies-literature
UnknownCommentary on a Clinical Trial of Spesolimab, a Humanized Anti-interleukin-36 Receptor Monoclonal Antibody, in Generalized Pustular Psoriasis.
Not available
S-EPMC9674804 | biostudies-literature
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