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TranscriptomicsTranscriptional effect of aft1 and aft2 mutation in iron depleted conditions
The paralogous transcription factors Aft1p and Aft2p activate the expression of genes involved in iron metabolism under iron depleted conditions. Both are able to bind to the same DNA consensus sequence in vitro. We used DNA microarrays and loss of function mutant strains to better understand the re...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-1763 | biostudies-arrayexpress
TranscriptomicsmRNA composition of IRP1 mRNPs in mouse tissues
Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation with IRP1 (iron regulatory protein 1). Reference Sanchez at al., 2007 Nat. Protoc. Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation ...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-17096 | biostudies-arrayexpress
TranscriptomicsmRNA composition of IRP2 mRNPs in mouse tissues
Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation with IRP2 (iron regulatory protein 2). Reference Sanchez at al., 2007 Nat. Protoc. Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation ...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-17097 | biostudies-arrayexpress
UnknownSIREs: searching for iron-responsive elements.
Not available
S-EPMC2896125 | biostudies-literature
GenomicsIron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer’s disease
Iron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer’s disease
PRJNA627459 | ENA
TranscriptomicsIron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer’s disease
Background: Iron trafficking and accumulation has been associated with Alzheimer’s disease (AD) pathogenesis. However, the role of iron dyshomeostasis in early disease stages is uncertain. Currently, gene expression changes indicative of iron dyshomeostasis are not well characterised, making it diff...
ORGANISM(S): Danio rerio 
2020-05-06 | GSE149149 | GEO
TranscriptomicsExpression profile of trace metal element responsive genes in Brassica rapa
Purpose: Zinc deficiency (ZnD) and iron deficiency (FeD), excess Zn (ZnE) and cadmium exposure (CdE) are major environmental problems for crop cultivation. Methods: Applying Tag-Seq technology to leaves of Brassica rapa grown under FeD, ZnD, ZnE or CdE conditions, with normal conditions as a control...
ORGANISM(S): Brassica rapa 
2014-09-30 | E-GEOD-55264 | biostudies-arrayexpress
UnknownConservation in the Iron Responsive Element Family.
Not available
S-EPMC8466369 | biostudies-literature
TranscriptomicsTranscription profiling of human 786-O clear cell renal carcinoma cells reveals small molecule inhibitors of HIF-2a translation link its 5 UTR Iron-Responsive Element (IRE) to oxygen sensing
Cells transiently adapt to hypoxia by globally decreasing protein translation. However, specific proteins needed to respond to hypoxia evade this translational repression. The mechanisms of this phenomenon remain unclear. We screened for and identified small molecules that selectively decrease HIF-2...
ORGANISM(S): Homo sapiens 
2009-01-14 | E-GEOD-13818 | biostudies-arrayexpress
GenomicsDiurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms
Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms
PRJNA1016416 | ENA
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