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MetabolomicsAftpo3 and Afdur3, the Aspergillus fumigatus Plasma Membrane Transporters of Polyamines, Regulate Polyamine Homeostasis and Itraconazole Susceptibility

Aspergillus fumigatus is a notorious opportunistic pathogen that causes Invasive Aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Long-term antifungal drug azole abuse in clinical treatment and agriculture renders it ineffectual or drug resistant. Drug resistance...

2020-12-21 | MTBLS1739 | MetaboLights
ProteomicsCutaneous squamous cell carcinoma A431 cells with itraconazole
Our objective is exploring the therapeutic potential of itraconazole in cSCC and investigate its molecular mechanism.Transcriptomic and proteomic analyses were used to explore the underlying anti-cancer mechanism.
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD030984 | Pride
A431  itraconazole 
TranscriptomicsRNA-Seq of Aspergillus fumigatus mutants resistant to itraconazole, SYBARIS project.
Two mutant strains of Aspergillus fumigatus derived from strain A1160, HapB and 29.9, display resistance to the antifungal drug itraconazole. To understand what underlying transcriptional processes contribute to this resistance, A1160, HapB and 29.9 were cultured either in the presence or absence of...
ORGANISM(S): Aspergillus fumigatus 
2016-04-30 | E-SYBR-5 | biostudies-arrayexpress
GenomicsCutaneous squamous cell carcinoma A431 cells treated with itraconazole
Cutaneous squamous cell carcinoma A431 cells treated with itraconazole
PRJNA789491 | ENA
TranscriptomicsCutaneous squamous cell carcinoma A431 cells treated with itraconazole
The role of itraconazole in cSCC was still unclear. Our objective is to explore the therapeutic potential of itraconazole in cSCC and investigate its molecular mechanism. We proved itraconazole inhibits the growth of cSCC by several pathways.
ORGANISM(S): Homo sapiens 
2022-01-25 | GSE191037 | GEO
GenomicsRNA-Seq of Aspergillus fumigatus mutants resistant to itraconazole
RNA-Seq of Aspergillus fumigatus mutants resistant to itraconazole
PRJEB1586 | ENA
TranscriptomicsIdentifying the molecular mode of action of itraconazole in colorectal cancer
Two cell lines (HT55 and SW948) were found responsive to itraconazole treatment. To identify the mode of action cells were treated with itraconazole or control (DMSO) and then subjected to RNAseq analysis once the phenotype had developed
ORGANISM(S): Homo sapiens 
2018-05-21 | GSE114013 | GEO
TranscriptomicsExploring gene expression signatures of itraconazole for infantile hemangioma endothelial cell in vitro
In order to understand the mechanisms underlying the effects of itraconazole in infantile hemangioma endothelial cells, we further explored the potential targeting genes of itraconazole in infantile hemangioma endothelial cells in vitro by using a genome-wide gene expression array. In total 172 mRNA...
ORGANISM(S): Homo sapiens 
2021-11-29 | GSE123108 | GEO
GenomicsExploring gene expression signatures of itraconazole for infantile hemangioma endothelial cell in vitro
Exploring gene expression signatures of itraconazole for infantile hemangioma endothelial cell in vitro
PRJNA507567 | ENA
GenomicsIdentifying the molecular mode of action of itraconazole in colorectal cancer
Identifying the molecular mode of action of itraconazole in colorectal cancer
PRJNA454881 | ENA
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