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MetabolomicsInduction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer

Tumor-initiating cells (TICs) tend to reside in poorly vascularized regions of tumors and are subjected to nutrient stress. How TICs activate metabolic plasticity for adapting to periods of low nutrient availability, especially during glucose-limiting conditions, has remained unclarified. Here, w...

2025-09-29 | MTBLS8430 | MetaboLights
MetabolomicsMaternal MASLD rewires milk bile-acid hydrophobicity to restrict microbiome-dependent neonatal ketone supply_milk

Maternal metabolic dysfunction-associated steatotic liver disease (MASLD) in mice creates a paradoxical neonatal ketone deficit during nursing, despite preserved hepatic ketogenesis, that precedes adult spatial memory impairment. Vulnerable litters show reduced β-hydroxybutyrate (β-HB) in the int...

2026-08-02 | MTBLS15225 | MetaboLights
MetabolomicsMaternal MASLD rewires milk bile-acid hydrophobicity to restrict microbiome-dependent neonatal ketone supply_hippocampus
Maternal metabolic dysfunction-associated steatotic liver disease (MASLD) in mice creates a paradoxical neonatal ketone deficit during nursing, despite preserved hepatic ketogenesis, that precedes adult spatial memory impairment. Vulnerable litters show reduced β-hydroxybutyrate (β-HB) in the intest...
2026-08-02 | MTBLS15224 | MetaboLights
MetabolomicsImidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model
Ferroptosis is a form of regulated cell death that can be induced by inhibition of the cystine-glutamate antiporter, system xc-. Among the existing system xc- inhibitors, imidazole ketone erastin (IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially s...
2019-04-17 | MTBLS774 | MetaboLights
GenomicsTargeting Ketone Body Metabolism in Mitigating Gemcitabine Resistance
Targeting Ketone Body Metabolism in Mitigating Gemcitabine Resistance
PRJNA1176263 | ENA
MetabolomicsOral ketone monoester ingestion reduces circulating blood glucose, exogenous carbohydrate oxidation and oxidation efficiency in trained male cyclists when fed 120 g of CHO per hour during exercise

We examined the effects of ketone monoester (KME) and carbohydrate (CHO) co-ingestion on exogenous CHO oxidation, metabolomic responses and exercise capacity. In a randomised repeated-measures design (after a 36 h CHO loading protocol and pre-exercise meal of 12 and 2 g.kg-1, respectively), eight...

2026-04-22 | MTBLS6260 | MetaboLights
GenomicsDietary restriction promotes anti-tumor immunity via T cell mediated ketone body metabolism
Dietary restriction promotes anti-tumor immunity via T cell mediated ketone body metabolism
PRJNA1109515 | ENA
GenomicsKetone body β-hydroxybutyrate restores Tau proteostasis via metabolism-independent mechanism
Ketone body β-hydroxybutyrate restores Tau proteostasis via metabolism-independent mechanism
PRJNA1392210 | ENA
UnknownCardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.
Not available
S-EPMC4209361 | biostudies-literature
Proteomicsβ-Hydroxybutyrylation in Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM) is characterized by metabolic remodeling and energetic stress independent of coronary artery disease. Increased reliance on fatty acid and ketone body metabolism has been observed in DCM, but the regulatory mechanisms linking altered substrate utilization to myocardial ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD066713 | Pride
Diabetic cardiomyopathy  β-hydroxybutyrylation (kbhb)  metabolic remodeling  ketone body metabolism  mitochondrial regulation 
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