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TranscriptomicsMicroarray comparing gene expression changes between control, normoglycaemic mice, and mice expressing the human neonatal diabetes mutation Kir6.2-V59M in pancreatic beta-cells left diabetic for 2 weeks
Activating mutations in the KATP channel cause a rare genetic form of diabetes called neonatal diabetes. These mutations render the channel permanently open results in membrane hyperpolarisation of the pancreatic beta-cell. This prevents calcium influx and impairs insulin secretion. Mice expressing ...
ORGANISM(S): Mus musculus 
2017-07-05 | E-MTAB-5086 | biostudies-arrayexpress
UnknownEffects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
Not available
S-EPMC1572697 | biostudies-literature
UnknownKir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.
Not available
S-EPMC1173155 | biostudies-literature
ProteomicsMechanism of pharmacochaperoning in ATP-sensitive potassium channels revealed by cryo-EM
ATP-sensitive potassium (K-ATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic beta-cells to maintain glucose homeostasis. Mutations that impair channel folding or assembly prevent ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-12 | PXD014498 | Pride
Pharmacological chaperones  sulfonylureas  glinides  carbamazepine  sulfonylurea receptor 1  kir6.2  structure 
UnknownAn in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.
Not available
S-EPMC7611921 | biostudies-literature
UnknownSulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.
Not available
S-EPMC4210431 | biostudies-literature
UnknownPhentolamine block of KATP channels is mediated by Kir6.2.
Not available
S-EPMC23609 | biostudies-literature
UnknownFlexibility of the Kir6.2 inward rectifier K(+) channel pore.
Not available
S-EPMC31207 | biostudies-literature
UnknownKir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
Not available
S-EPMC1576033 | biostudies-literature
UnknownKir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation.
Not available
S-EPMC8577462 | biostudies-literature
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