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MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
MetabolomicsChronic Exposure to Environmentally Relevant Doses of Butyl Benzyl Phthalate Promotes Development of Breast Tumor Via the Tricarboxylic Acid Cycle and Fatty Acid β-oxidation

This study investigates the proliferative effects of environmentally relevant exposure to butyl benzyl phthalate (BBP) on triple-negative breast cancer using integrated in vivo and in vitro approaches.

2025-12-06 | MTBLS13467 | MetaboLights
UnknownDystrophinopathy-associated dysfunction of Krebs cycle metabolism.
Not available
S-EPMC6400043 | biostudies-literature
UnknownSulfate radicals enable a non-enzymatic Krebs cycle precursor.
Not available
S-EPMC5455955 | biostudies-literature
UnknownPlasma Krebs Cycle Intermediates in Nonalcoholic Fatty Liver Disease.
Not available
S-EPMC7073566 | biostudies-literature
GenomicsTargeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-Ribose Polymerase inhibitors and low-dose alkylating chemotherapy
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-Ribose Polymerase inhibitors and low-dose alkylating chemotherapy
PRJNA842446 | ENA
UnknownMetals promote sequences of the reverse Krebs cycle.
Not available
S-EPMC5659384 | biostudies-literature
UnknownMutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.
Not available
S-EPMC5223029 | biostudies-literature
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