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MetabolomicsLactobacillus rhamnosus B16 Regulates Lipid Metabolism Homeostasis by Producing Acetic Acid

Background Hyperlipidemia, a chronic disorder caused by abnormal lipid metabolism, increases risks of atherosclerosis and cardiovascular diseases. 

Current single-target drugs have limited efficacy and side effects, prompting interest in probiotics like Lactobacillus rhamnosus, though ...

2025-08-14 | MTBLS12858 | MetaboLights
TranscriptomicsDose-dependent immunomodulation of human dendritic cells by the probiotic Lactobacillus rhamnosus Lcr35
Gene expression changes in human dendritic cells after contact with either 10e4 or 10e7 CFU of Lactobacillus rhamnosus Lcr35 Bacterial cells were incubated for 3 hours with dendritic cells. Total RNA was extracted, quantified, and labeled with Cy3 or Cy5 (control, dendritic cells without bacteria). ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-25699 | biostudies-arrayexpress
MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
TranscriptomicsLysate affects on keratinocyte scratch assays
The aim of this study was to provide proof of principle as to whether probiotic bacteria or their extracts, could stimulate cutaneous wound healing. To this end, we have used a keratinocyte monolayer scratch assay which assesses one important aspect of wound healing, re-epithelialization. Primary hu...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-MTAB-3485 | biostudies-arrayexpress
TranscriptomicsSynbiotic impact of tagatose on viability of Lactobacillus rhamnosus strain GG mediated by the phosphotransferase system (PTS)
The presence of tagatose in Lactobacillus rhamnosus strain GG caused induction of a large number of genes associated with carbohydrate metabolism including the phosphotransferase system. In addition, these results indicate the tagatose enhanced the growth of Lactobacillus casei 01 and Lactobacillus ...
ORGANISM(S): Lactobacillus rhamnosus GG 
2013-09-19 | E-GEOD-41073 | biostudies-arrayexpress
MetabolomicsLactobacillus rhamnosus GG (LGG) exhibits inhibitory effects against non-small cell lung cancer (NSCLC) and alleviates the adverse effects associated with gefitinib_Metabolite study of culture medium supernatant

After screening the bacteria both in vivo and in vitro, it was found that a certain candidate strain could significantly inhibit non-small cell lung cancer when combined with the drug gefitinib and alleviate the side effects of gefitinib. Next, the mechanis...

2026-09-03 | MTBLS13843 | MetaboLights
TranscriptomicsResponse of Candida albicans to Lactobacillus rhamnosus
The bacterium Lactobacillus rhamnosus antagonizes the fungus Candida albicans. The transcriptional response of C. albicans to the presence of L. rhamnosus in an in vitro infection model with and without antibiotic treatment was investigated using microarrays.
ORGANISM(S): Candida albicans 
2022-04-27 | E-MTAB-11090 | biostudies-arrayexpress
ProteomicsSurfacome analysis of Lactobacillus rhamnosus GG and Lactobacillus rhamnosus Lc705
The present study reports comparative surfacomics (study of cell-surface exposed proteins) of the probiotic Lactobacillus rhamnosus strain GG and the dairy strain Lc705.
ORGANISM(S): Lactobacillus 
2016-07-01 | PXD001201 | Pride
Cell-surface bound proteins L. rhamnosus gg and l. rhamnosus lc705 Lc-ms/ms 
MetabolomicsLactobacillus rhamnosus GG (LGG) exhibits inhibitory effects against non-small cell lung cancer (NSCLC) and alleviates the adverse effects associated with gefitinib_Serum metabolomics study in mice

After screening the bacteria both in vivo and in vitro, it was found that a certain candidate strain could significantly inhibit non-small cell lung cancer when combined with the drug gefitinib and alleviate the side effects of gefitinib. Next, the mechanism will be explored through in vivo and i...

2026-09-03 | MTBLS13812 | MetaboLights
MetabolomicsLactobacillus rhamnosus GG (LGG) exhibits inhibitory effects against non-small cell lung cancer (NSCLC) and alleviates the adverse effects associated with gefitinib_Fecal metabolomics study in mice

After screening the bacteria both in vivo and in vitro, it was found that a certain candidate strain could significantly inhibit non-small cell lung cancer when combined with the drug gefitinib and alleviate the side effects of gefitinib. Next, the mechanism will be explored through in vivo and i...

2026-09-03 | MTBLS13811 | MetaboLights
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