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ProteomicsUV-crosslinking mapping of LARP6 interaction sites with RNA
To map the regions of LARP6 that interacts directly with RNA, we developed a mass spectrometry-based approach termed IP-OOPS (Immunoprecipitation coupled with Orthogonal Organic Phase Separation. This approach combines the isolation of UV-C crosslinked RNA–protein adducts via Orthogonal Organic Phas...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD064029 | Pride
Lc-ms/ms  rna-protein interactions  organic phase separation  rna crosslinking 
TranscriptomicsQUANTSEQ 3' sequencing of protrusions and cell bodies of control (NT) or LARP6 siRNA (LARP6 KD) transfected MDA-MB231 breast cancer cells
To assess how LARP6 affects mRNA localisation to cell-protrusions, we transfected MDA-MB231 cells with either non-targeting control siRNA or LARP6 siRNA for 72 hrs, before fractionating the cells into protrusion and cell-bodies, and analysed total RNA from each fraction via Lexogen QUANTSEQ FWD 3' m...
ORGANISM(S): Homo sapiens 
2020-10-30 | E-MTAB-9520 | biostudies-arrayexpress
ProteomicsTargeting endoplasmic reticulum-anchored CRTH2 binding to LARP6 ameliorates organ fibrosis
Excessive deposition of extracellular matrix, mainly collagen protein, is the hallmark of organ fibrosis. The molecular mechanisms of the regulation of fibrotic protein biosynthesis are unclear. Here, we found that chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a cell m...
ORGANISM(S): Mus Sp. 
2021-04-25 | PXD025610 |
GenomicsLARP6 shapes the mRNA translation of fibrogenic genes [eCLIP]
LARP6 shapes the mRNA translation of fibrogenic genes [eCLIP]
PRJNA1168517 | ENA
GenomicsLARP6 shapes the mRNA translation of fibrogenic genes [RNA-seq]
LARP6 shapes the mRNA translation of fibrogenic genes [RNA-seq]
PRJNA1170287 | ENA
TranscriptomicsLARP6 shapes the mRNA translation of fibrogenic genes [eCLIP]
Metabolic syndrome and excessive alcohol consumption result in liver injury and fibrosis, which is characterized by an increased collagen production by activated Hepatic Stellate Cells (HSCs). LARP6, an RNA-binding protein, was shown to facilitate collagen production. However, LARP6 expression and f...
ORGANISM(S): Homo sapiens 
2026-02-17 | GSE278725 | GEO
GenomicsCardiomyocyte-specific LARP6 overexpression prevents Angiotensin II-induced myocardial dysfunction and interstitial fibrosis
Cardiomyocyte-specific LARP6 overexpression prevents Angiotensin II-induced myocardial dysfunction and interstitial fibrosis
PRJNA1198339 | ENA
GenomicsQUANTSEQ 3' sequencing of protrusions and cell bodies of control (NT) or LARP6 siRNA (LARP6 KD) transfected MDA-MB231 breast cancer cells
QUANTSEQ 3' sequencing of protrusions and cell bodies of control (NT) or LARP6 siRNA (LARP6 KD) transfected MDA-MB231 breast cancer cells
PRJEB40219 | ENA
TranscriptomicsLARP6 shapes the mRNA translation of fibrogenic genes [RNA-seq]
Metabolic syndrome and excessive alcohol consumption result in liver injury and fibrosis, which is characterized by an increased collagen production by activated Hepatic Stellate Cells (HSCs). LARP6, an RNA-binding protein, was shown to facilitate collagen production. However, LARP6 expression and f...
ORGANISM(S): Homo sapiens 
2026-02-17 | GSE279064 | GEO
GenomicsAnalysis of LARP6 impact on RNA localisation to cell protrusions of Glioblastoma cells
Analysis of LARP6 impact on RNA localisation to cell protrusions of Glioblastoma cells
PRJNA1401729 | ENA
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