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ProteomicsProteomics reveals the inhibitory mechanism of Levodopa against esophageal squamous cell carcinoma
The high recurrence rate and poor survival prospects of esophageal squamous cell carcinoma (ESCC) patients after treatment make the ongoing research on chemoprevention drugs for ESCC particularly important. In helping to solve this problem, we screened a large number of FDA-approved drugs and found ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013824 | Pride
Mitochondria Levodopa Chemoprevention Esophageal squamous cell carcinoma (escc) 
TranscriptomicsEffect of zonisamide co-administration with levodopa on global gene expression in the striata of rats with ParkinsonM-bM-^@M-^Ys disease
The anti-epileptic drug zonisamide is reported to exert beneficial effects in patients with Parkinson's disease. To elucidate the pathophysiological mechanisms underlying the anti-parkinsonism effects of zonisamide, we examined the effect of zonisamide co-administered with levodopa in the striata of...
ORGANISM(S): Rattus norvegicus 
2012-10-30 | E-GEOD-39980 | biostudies-arrayexpress
TranscriptomicsMolecular Adaptations of Striatal Spiny Projection Neurons During Levodopa-Induced Dyskinesia
L-3,4-dihydroxyphenylalanine (levodopa) treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). While it is known that striatal spiny projection neurons (SPNs) are involved in ...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55096 | biostudies-arrayexpress
GenomicsRiluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
Riluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
PRJNA734572 | ENA
Methylation profilingRiluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
Dyskinesias are characterized by abnormal repetitive involuntary movements due to dysfunctional neuronal activity. Although levodopa-induced dyskinesia, characterized by tic-like abnormal involuntary movements, has no clinical treatment for Parkinson’s disease patients, animal studies indicate that ...
ORGANISM(S): Rattus norvegicus 
2021-06-03 | GSE176004 | GEO
TranscriptomicsMolecular Adaptations of Striatal Spiny Projection Neurons During Levodopa-Induced Dyskinesia
L-3,4-dihydroxyphenylalanine (levodopa) treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). While it is known that striatal spiny projection neurons (SPNs) are involved in ...
ORGANISM(S): Mus musculus 
2014-03-03 | GSE55096 | GEO
UnknownVery-Low-Dose Levodopa Therapy for Pediatric Neurological Disorders: A Preliminary Questionnaire in Japan.
Not available
S-EPMC7970027 | biostudies-literature
Methylation profilingDynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia
Levodopa-induced dyskinesia (LID) is a persistent behavioral sensitization that develops after repeated levodopa (L-DOPA) exposure in Parkinson disease (PD) patients. we used reduced representation bisulfite sequencing to determine the methylation status of cytosines genome wide at base pair resolut...
ORGANISM(S): Rattus norvegicus 
2016-06-16 | GSE83385 | GEO
TranscriptomicsEffect of zonisamide co-administration with levodopa on global gene expression in the striata of rats with Parkinson’s disease
The anti-epileptic drug zonisamide is reported to exert beneficial effects in patients with Parkinson's disease. To elucidate the pathophysiological mechanisms underlying the anti-parkinsonism effects of zonisamide, we examined the effect of zonisamide co-administered with levodopa in the striata of...
ORGANISM(S): Rattus norvegicus 
2012-10-30 | GSE39980 | GEO
TranscriptomicsBulk RNA-seq of striatum of 6-OHDA lesioned rats exposed to levodopa/benserazide and trapidil
Gene expression changes in striatum of 6-OHDA lesioned female Sprague Dawley rats due to 14 days of daily dosing of levodopa/benserazide with or without trapidil.
ORGANISM(S): Rattus norvegicus 
2026-07-15 | GSE278287 | GEO
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