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TranscriptomicsAdiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism.
The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in adiponectin knockout (KO) and wild-type (WT) mice by RNA-Seq. Comparing to WT mice, adiponectin KO mice exhibited decreased mRNA expression of rate-...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-38144 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomic analysis reveals the regulatory networks of elovl6 on lipid and glucose metabolism in zebrafish
Elongation of very long-chain fatty acids protein 6 (Elovl6) has been reported to be associated with clinical treatments of a variety of metabolic diseases. However, there is no systematic and comprehensive study to reveal the regulatory role of Elovl6 in the mRNA, protein and phosphorylation levels...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2020-05-27 | PXD017702 | Pride
Zebrafish  elovl6 knockout  transcriptomics  proteomics  phosphoproteomics  lipid/glucose metabolism 
TranscriptomicsCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-b...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-32357 | biostudies-arrayexpress
ProteomicsHepatic proteomic analysis of selenoprotein T knockout mice by TMT: Implications for the role of selenoprotein T in glucose and lipid metabolism
Selenoprotein T (SELENOT, SelT), a thioredoxin-like enzyme, exerts an essential oxidoreductase activity in the endoplasmic reticulum. However, its precise function remains unknown. To gain more understanding of SELENOT function, a conventional SELENOT knockout (KO) mouse model was constructed for th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD023261 | Pride
Selenoprotein t  knockout  proteomics  tmt  glucose and lipid metabolism 
TranscriptomicsMolecular characterization of supraclavicular and subcutaneous abdominal adipose tissue samples collected during CE (cold exposure) and TN (thermoneutral) conditions
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. To gain insight regarding the mechanisms of accelerated lipid metabolism in relation to the cold-a...
ORGANISM(S): Homo sapiens 
2016-05-26 | E-MTAB-4031 | biostudies-arrayexpress
ProteomicsSpontaneous nonsense mutation in Tuft1 (tuftelin 1) gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat
A new spontaneous mutation, abnormal hair appearance in the rat, has been identified as a non-functional Tuft1 (tuftelin 1) gene. The pleiotropic effects of this mutation regulate glucose and lipid metabolism. Analysis of the liver proteome revealed possible molecular mechanisms for the metabolic ef...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-03-12 | PXD045880 | Pride
Hepatic proteome  lipid and glucose metabolism  rat  spontaneous nonsense mutation  tuft1 (tuftelin 1) gene 
UnknownSENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation.
Not available
S-EPMC10066554 | biostudies-literature
TranscriptomicsPPARM-NM-4 activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference.
The role of peroxisome proliferator-activated receptor M-NM-4 (PPARM-NM-4) activation on global gene expression and mitochondrial fuel utilization were investigated in human myotubes. Only 21 genes were up-regulated and 3 genes were down-regulated after activation by the PPARM-NM-4 agonist GW501516....
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-40789 | biostudies-arrayexpress
MetabolomicsZhaqu Compound Improves Glucose and Lipid Metabolism in T2DM with MASLD by Modulating Gut Microbiota and PPARγ

Type 2 diabetes mellitus (T2DM) with metabolic syndrome-associated steatohepatitis (MASLD) is a complex metabolic comorbidity characterized by hyperglycemia, pancreatic β-cell dysfunction, and hepatic lipid metabolism disorders, in which gut microbiota dysbiosis and abnormal PPARγ signaling play ...

2026-02-25 | MTBLS13933 | MetaboLights
UnknownCTRP13 ablation improves systemic glucose and lipid metabolism.
Not available
S-EPMC10598410 | biostudies-literature
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