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MetabolomicsSystematic analyses of lipid mobilization by human lipid transfer proteins

Lipid transfer proteins (LTPs) maintain the specialised lipid compositions of biological membranes, and many are associated with disease. In eukaryotes, they support organellar functions by transporting lipids between compartmentalised metabolic pathways. However, for the majority of the hundreds...

2025-11-14 | MTBLS9567 | MetaboLights
MetabolomicsMaternal lipid mobilization is essential for embryonic development in a key malaria vector
Lipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we ...
2024-11-05 | MTBLS9881 | MetaboLights
ProteomicsMulti-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma patients – proteins from serum samples of melanoma patients with high tumor load
Pathophysiology of cancer-associated syndroms such as cachexia is poorly understood and no routine biomarkers have been established, yet. Using shotgun proteomics, known marker molecules including PMEL, CRP, SAA and CSPG4 were found deregulated in patients with metastatic melanoma. Targeted analysis...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-31 | MSV000083385 | MassIVE
TranscriptomicsTranscriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue
Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-43658 | biostudies-arrayexpress
GenomicsTranscriptional determinants of lipid mobilization in human adipocytes [Microarray]
Transcriptional determinants of lipid mobilization in human adipocytes [Microarray]
PRJNA1040769 | ENA
MetabolomicsMetabolic plasticity of lipid storage and utilization governs fungal persister formation within macrophages
The ability of Candida glabrata to survive within macrophages creates a reservoir for recurrent infections and antifungal failure, yet the underlying mechanisms remain elusive. Here, using a host-mimicking in vitro evolution model, we identify asparagine synthetase (ASN2) as a critical genetic deter...
2026-04-22 | MTBLS14351 | MetaboLights
ProteomicsTMEM41B is a novel regulator of autophagy and lipid mobilization
Autophagy maintains cellular homeostasis by targeting damaged organelles, pathogens or misfolded protein aggregates for lysosomal degradation. The autophagic process is initiated by the formation of autophagosomes, which can selectively enclose cargo via autophagy cargo receptors. A machinery of wel...
ORGANISM(S): Homo sapiens (Human) 
2018-08-20 | PXD010207 | Pride
Autophagy/ contact sites/ crispr/ lipid droplets/ tmem41b 
GenomicsTranscriptional determinants of lipid mobilization in human adipocytes [CUT&Tag]
Transcriptional determinants of lipid mobilization in human adipocytes [CUT&Tag]
PRJNA1040780 | ENA
GenomicsTranscriptional determinants of lipid mobilization in human adipocytes [ATAC-seq]
Transcriptional determinants of lipid mobilization in human adipocytes [ATAC-seq]
PRJNA1040781 | ENA
GenomicsTranscriptional determinants of lipid mobilization in human adipocytes [ChIP-seq]
Transcriptional determinants of lipid mobilization in human adipocytes [ChIP-seq]
PRJNA1040770 | ENA
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