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MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
UnknownTissue-specific strategies of the very-long chain acyl-CoA dehydrogenase-deficient (VLCAD-/-) mouse to compensate a defective fatty acid β-oxidation.
Not available
S-EPMC3443214 | biostudies-literature
UnknownStructural Basis for Expanded Substrate Specificities of Human Long Chain Acyl-CoA Dehydrogenase and Related Acyl- CoA Dehydrogenases.
Not available
S-EPMC10925408 | biostudies-literature
UnknownVery long-/ and long Chain-3-Hydroxy Acyl CoA Dehydrogenase Deficiency correlates with deregulation of the mitochondrial fusion/fission machinery.
Not available
S-EPMC5818531 | biostudies-literature
ProteomicsLong-Chain Acyl Coenzyme A Dehydrogenase, a Key Player in Metabolic Rewiring/Invasiveness in Experimental Tumors and Human Mesothelioma Cell Lines
Cross-species investigations of cancer invasiveness are a new approach that has already identified new biomarkers which are potentially useful for improving tumor diagnosis and prognosis in clinical medicine and veterinary science. In this study, we combined proteomic analysis of four experimental r...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-06-20 | PXD042942 | Pride
Malignant mesothelioma  metabolism  mitochondria  long-chain specific acyl-coa dehydrogenase  fatty acid β-oxidation  biomarker 
UnknownStrategies for correcting very long chain acyl-CoA dehydrogenase deficiency.
Not available
S-EPMC4400356 | biostudies-literature
UnknownVery Long-Chain Acyl-CoA Dehydrogenase Deficiency: High Incidence of Detected Patients With Expanded Newborn Screening Program.
Not available
S-EPMC8110899 | biostudies-literature
UnknownDevelopment of a Tandem Mass Spectrometry Method for Rapid Measurement of Medium- and Very-Long-Chain Acyl-CoA Dehydrogenase Activity in Fibroblasts.
Not available
S-EPMC5585096 | biostudies-literature
UnknownDiagnosis, Treatment, and Clinical Outcome of Patients with Mitochondrial Trifunctional Protein/Long-Chain 3-Hydroxy Acyl-CoA Dehydrogenase Deficiency.
Not available
S-EPMC5388644 | biostudies-literature
UnknownNutritional ketosis improves exercise metabolism in patients with very long-chain acyl-CoA dehydrogenase deficiency.
Not available
S-EPMC7384182 | biostudies-literature
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