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ProteomicsE3 ubiquitin-ligase Hakai induces LRP4 degradation and regulates Wnt/β-catenin signalling in colorectal cancer cells
The epithelial-mesenchymal transition (EMT) is closely linked to the acquisition of cancer stem cell (CSC) properties, which contribute to treatment resistance and metastasis. This study investigates the role of the E3 ubiquitin-ligase Hakai, the first identified post-translational regulator of E-ca...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD069248 | Pride
E3 ubiquitin-ligase hakai  lrp4  wnt/β-catenin pathway  cancer stem cell  colon cancer. 
UnknownSynapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway.
Not available
S-EPMC8180081 | biostudies-literature
UnknownDeficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development.
Not available
S-EPMC11105680 | biostudies-literature
UnknownLrp4 in astrocytes modulates glutamatergic transmission.
Not available
S-EPMC4961622 | biostudies-literature
GenomicsApoe3 Enhances Acetylcholine Receptor Clustering via Lrp4
Apoe3 Enhances Acetylcholine Receptor Clustering via Lrp4
PRJNA1378828 | ENA
UnknownLRP4 serves as a coreceptor of agrin.
Not available
S-EPMC2743173 | biostudies-literature
UnknownLRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron.
Not available
S-EPMC7730773 | biostudies-literature
UnknownThe synaptic receptor Lrp4 promotes peripheral nerve regeneration.
Not available
S-EPMC6008306 | biostudies-literature
UnknownStructural basis of agrin-LRP4-MuSK signaling.
Not available
S-EPMC3278892 | biostudies-literature
UnknownAgrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).
Not available
S-EPMC3220470 | biostudies-literature
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