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MetabolomicsMetabolomics of Lin-Sca1+Kit+ (LSK) cells in NM mice
Not available
ORGANISM(S): Mus musculus 
ST000769 | MetabolomicsWorkbench
TranscriptomicsSingle cell RNA sequencing of LSK (lineage negative, Sca-1+, c-Kit+) cells isolated by fluorescence-activated cell sorting from the bone marrow of control young C57Bl/6Jax mice
Hematopoietic stem cells (HSCs) and different multipotent progenitor populations (MPPs) contained in the Lin- Sca-1+ c-Kit+ (LSK) compartment have previously been identified using diverse surface marker panels. However, a comprehensive and complete characterization of the complete LSK compartment is...
ORGANISM(S): Mus musculus 
2021-05-13 | E-MTAB-9208 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of wild-type and Brpf1-null fetal liver LSK cells
To compare the impact of hematopoietic-specific Brpf1 gene inactivation, LSK (Lin-Sca1+cKit1+) cells were sorted from wild-type and Brpf1-null fetal liver cells for RNA-Seq. Four E14.5 embryos were used to pool sufficient LSK cells for total RNA isolation and subsequent sequencing on HiSq2500. Two i...
ORGANISM(S): Mus musculus 
2016-08-10 | E-GEOD-83483 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and GABPalpha-deficient Flt3(-) LSK cells
GABPalpha is an Ets family transcription factor and involved in regulation of both basic cellular functions such as cell cycle progression and tissue-specific biological processes. We found that GABPalpha is critically required for survival and differentiation of hematopoietic stem cells. We used mi...
ORGANISM(S): Mus musculus 
2011-07-27 | E-GEOD-23341 | biostudies-arrayexpress
UnknownLSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells.
Not available
S-EPMC3366951 | biostudies-literature
MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12491 | MetaboLights
MetabolomicsEMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress
The long-term maintenance of hematopoietic stem cells (HSCs) relies on the regulation of endoplasmic reticulum (ER) stress at a low level, but the underlying mechanism remains poorly understood. Here, we demonstrate that suppression of ER stress improves the functions of HSCs and protects HSCs again...
2025-06-04 | MTBLS12489 | MetaboLights
TranscriptomicsIdentify gene expression signatures in the niche cells (CD45 negative) during proliferation of Hematopoietic stem cells (LSK)
To further identify gene expression signatures in the niche cells (CD45 negative) during proliferation of Hematopoietic stem cells (LSK), we employed mice whole genome (60K) microarray expression profiling as a discovery platform to identify the up-regulated and down-regulated genes of the niche. [S...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-75294 | biostudies-arrayexpress
TranscriptomicsGenes affected by PAD4 deficiency in LSK cells obtained from mouse bone marrow.
We found PAD4, which is one of the transcriptional co-regulator by histone modification, was highly expressed in lineage-, Sca-1+, c-kit+ (termed as LSK) cells of mouse bone marrow. To find the target genes which are regulated by PAD4 in LSK cells, we analyzed gene expression in PAD4-deficient mouse...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45482 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Cebpa knock-in mutant LSK hematopoietic stem cells
Gene expression of LSK (lin-Sca-Kit+) hematopoietic stem cells from wild type mice was compared with LSK from Cebpa knock-in mutant mice (K/K, K/L, and L/L mutants). Fetal liver cells for each genotype were competitively transplanted into irradiant recipients. Donor-derived LSK cells were isolated b...
ORGANISM(S): Mus musculus 
2009-11-03 | E-TABM-695 | biostudies-arrayexpress
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