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MetabolomicsLuteolin as a urease inhibitor: a novel therapeutic strategy against Helicobacter pylori

The rising prevalence of antibiotic-resistant Helicobacter pylori (H. pylori) underscores the urgent need for alternative treatment strategies. By producing ammonia to neutralize gastric acid, the key virulence factor urease is essential for H. pylori&nbs...

2026-02-28 | MTBLS13581 | MetaboLights
TranscriptomicsTranscription profiling of mouse microglia reveals luteolin has anti-inflammatory and neurotrophic effects on microglia
Our aim was to identify genes that were differentially expressed in microglia stimulated with Lipopolysaccharide, Luteolin, or both. Affymetrix microarrays were used to analyze RNA samples Experiment Overall Design: RNA from control BV-2 cells, and cells treated for 24h with LPS, Luteolin, or LPS+Lu...
ORGANISM(S): Mus musculus 
2010-01-23 | E-GEOD-18740 | biostudies-arrayexpress
TranscriptomicsmiRNA array analysis following gefinitib/luteolin administration to PC-3 cells
To determine if any altered miRNA expression is actually involved in the growth inhibition and/or cell death induction by luteolin and/or gefitinib, we performed miR-array analysis using RNA from PC-3 cells after 24h of treatment with 60μM luteolin and/or 60μM gefitinib. PC-3 cells were treated fo...
ORGANISM(S): Homo sapiens 
2014-06-29 | E-GEOD-53178 | biostudies-arrayexpress
TranscriptomicsInhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model [mRNA]
Chromatin acetylation is attributed with distinct functional relevance with respect to gene expression in normal and diseased conditions thereby leading to a topical interest in the concept of epigenetic modulators and therapy. We report here the identification and characterization of the acetylatio...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-75029 | biostudies-arrayexpress
ProteomicsProteomic analysis of the molecular targets of Luteolin in reducing DEHP accumulation in the liver
To identify candidate proteins involved in the reduction of DEHP by Luteolin, label-free proteomic analysis was performed on mouse PHs.
ORGANISM(S): Mus musculus (Mouse) 
2024-10-25 | PXD055165 | Pride
Primary mouse hepatocytes lc-ms/ 
TranscriptomicsMicroarray analysis following gefinitib/luteolin administration to PC-3 cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-53181 | biostudies-arrayexpress
TranscriptomicsLuteolin attenuates lipid dysregulation and insulin resistance thorough interplay of liver and adipose tissue in diet-induced obese mice
Analysis of effect of luteolin on lipid metabolism at gene expression level. The hypothesis tested in the present study was that luteolin treatment with obesogenic diet suppressed the hepatic lipogenesis pathways. Conversely, in adipose tissue, luteolin stimulated the lipogenesis pathway and it also...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-54189 | biostudies-arrayexpress
GenomicsHuman prostate cancer cell line, 22Rv1: Control vs. luteolin treatment
Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment
PRJNA523525 | ENA
GenomicsHuman prostate cancer cell line, 22Rv1: Control vs. luteolin treatment
Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment
PRJNA491894 | ENA
Genomicstranscriptome analysis for luteolin or siVRK1 treated ovarian cancer cells
transcriptome analysis for luteolin or siVRK1 treated ovarian cancer cells
PRJNA876224 | ENA
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