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MetabolomicsLactate-driven lysine lactylation mediates high-level colistin resistance in Salmonella
Intracellular pathogens are particularly refractory to antibiotic eradication, leading to persistent and relapsing infections. However, how intracellular metabolic microenvironments shape antibiotic resistance phenotypes remains poorly understood. Here we delineate a metabolic-regulatory axis wherei...
2026-06-17 | MTBLS14781 | MetaboLights
MetabolomicsA KRAS-triggered lactylation cascade forms the basis of chemotherapy resistance in colorectal cancer
KRAS-mutant colorectal cancer (KRASmut CRC) exhibits metabolic plasticity and chemoresistance, but the underlying mechanisms remain incompletely understood. Here, we show in CRC cells and organoids that KRAS-driven lactate accumulation promotes MCT1 K224 lactylation, which stabilizes mitochondrial M...
2026-10-16 | MTBLS16030 | MetaboLights
MetabolomicsA KRAS-triggered lactylation cascade forms the basis of chemotherapy resistance in colorectal cancer
KRAS-mutant colorectal cancer (KRASmut CRC) exhibits metabolic plasticity and chemoresistance, but the underlying mechanisms remain incompletely understood. Here, we show in CRC cells and organoids that KRAS-driven lactate accumulation promotes MCT1 K224 lactylation, which stabilizes mitochondrial M...
2026-10-16 | MTBLS16034 | MetaboLights
MetabolomicsA KRAS-triggered lactylation cascade forms the basis of chemotherapy resistance in colorectal cancer

KRAS-mutant colorectal cancer (KRASmut CRC) exhibits metabolic plasticity and chemoresistance, but the underlying mechanisms remain incompletely understood. Here, we show in CRC cells and organoids that KRAS-driven lactate accumulation promotes MCT1 K224 lactylation, which stabilizes mitochondria...

2026-10-16 | MTBLS16037 | MetaboLights
MetabolomicsA KRAS-triggered lactylation cascade forms the basis of chemotherapy resistance in colorectal cancer

KRAS-mutant colorectal cancer (KRASmut CRC) exhibits metabolic plasticity and chemoresistance, but the underlying mechanisms remain incompletely understood. Here, we show in CRC cells and organoids that KRAS-driven lactate accumulation promotes MCT1 K224 lactylation, which stabilizes mitochondria...

2026-10-16 | MTBLS16031 | MetaboLights
MetabolomicsProtein lactylation of citrate synthase promotes the AKI–CKD transition by activating the NLRP3 inflammasome.

Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, protein lactylation modification has emerged as a novel mechanism for mediating chronic organ damage. We investigated lactylated protein profiles and the role of...

2025-06-17 | MTBLS12606 | MetaboLights
MetabolomicsStreptococcus anginosus promotes hepatocellular carcinoma progression and BET inhibitor resistance by inducing BRD4 lactylation

Hepatocellular carcinoma (HCC) is a highly aggressive form of carcinoma with a poor prognosis. Diagnostic markers and potential therapeutic targets for HCC are urgently needed. Here, we demonstrate that fecal microbiota transplantation (FMT) using stool samples from HCC patients significantly pro...

2025-12-05 | MTBLS12398 | MetaboLights
ProteomicsSystematic profiling of lysine lactylation proteome reveals distinct changes in lactylation between the parental AGS cells and cisplatin-resistant AGS cells
Lactate enable to cause a novel post-translational modification, lactylation of proteins. We are interested in exploring whether lactate modulates DNA-damaging agents resistance in the form of lactylation. To gain a global view of DNA-damaging agents resistance-related lactylation, especially Kla of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-09 | PXD050906 | Pride
Lysine lactylation 
ProteomicsIdentification of lactate-induced PGK1 K131 lactylation in hepatocellular carcinoma cells
Lactate accumulation is an important metabolic feature of hepatocellular carcinoma and may regulate tumor progression through lactate-dependent post-translational modifications. In this study, we investigated whether lactate-induced protein lactylation contributes to the regulation of phosphoglycera...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD080849 | Pride
Human  hepatocellular carcinoma  hcc  lactate  protein lactylation  lysine lactylation  pgk1  k131  immunoprecipitation  lc-ms/ms  tandem mass spectrometry  post-translational modification 
ProteomicsGlobal Proteomic Analysis of Lysine lactylation in The Plant Pathogen Botrytis cinerea
Lysinelactylation , a recently discovered post-translational modification, plays a key role in the regulation of diverse cellular processes. Botrytis cinerea is a destructive necrotrophic fungal pathogen distributed worldwide with broad ranging hosts. However, the functions of Lysine lactylation ar...
ORGANISM(S): Trypanosoma brucei 
2020-09-07 | PXD020746 | Pride
Lc-ms/ms Botrytis cinerea Lysine lactylation 
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